含绿茶、辣椒素和生姜提取物的膳食补充剂对超重女性体重减轻及代谢指标的影响：一项随机双盲安慰剂对照临床试验

The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial.

作者信息

Taghizadeh Mohsen, Farzin Narjes, Taheri Sara, Mahlouji Mahnaz, Akbari Hossein, Karamali Fatemeh, Asemi Zatollah

机构信息

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

出版信息

Ann Nutr Metab. 2017;70(4):277-285. doi: 10.1159/000471889. Epub 2017 Jun 9.

DOI:10.1159/000471889

PMID:28595182

Abstract

BACKGROUND

This study was conducted to determine the effects of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles among overweight women.

METHODS

This randomized double-blind placebo-controlled clinical trial was implemented among 50 overweight women. Participants were randomly divided into 2 groups. Group A received dietary supplements containing 125 mg green tea, 25 mg capsaicin and 50 mg ginger extracts (n = 25) group B received placebos (n = 25) twice with lunch and twice with dinner daily for 8 weeks.

RESULTS

Compared with placebo, taking dietary supplements containing green tea, capsaicin and ginger resulted in a significant decrease in weight (-1.8 ± 1.5 vs. +0.4 ± 1.2 kg, respectively, p < 0.001) and body mass index (BMI; -0.7 ± 0.5 vs. +0.1 ± 0.5 kg/m2, respectively, p < 0.001). In addition, subjects who received green tea, capsaicin and ginger co-supplements had significantly decreased serum insulin concentrations (-2.6 ± 3.9 vs. -0.6 ± 2.0 µIU/mL, p = 0.02), homeostatic model of assessment for insulin resistance (-0.5 ± 0.8 vs. -0.05 ± 0.6, p = 0.01), and increased quantitative insulin sensitivity check index (+0.01 ± 0.01 vs. +0.001 ± 0.01, p = 0.008) and plasma glutathione (GSH) levels (+73.8 ± 120.6 vs. -28.3 ± 193.4 µmol/L, p = 0.03) compared with the placebo.

CONCLUSIONS

Our study indicated that taking green tea, capsaicin and ginger co-supplements for 8 weeks among overweight women had beneficial effects on weight, BMI, markers of insulin metabolism and plasma GSH levels.

摘要

背景

本研究旨在确定含有绿茶、辣椒素和生姜提取物的膳食补充剂对超重女性体重减轻和代谢状况的影响。

方法

本随机双盲安慰剂对照临床试验在50名超重女性中进行。参与者被随机分为两组。A组每天午餐和晚餐各服用两次含有125毫克绿茶、25毫克辣椒素和50毫克生姜提取物的膳食补充剂（n = 25），B组每天午餐和晚餐各服用两次安慰剂（n = 25），持续8周。

结果

与安慰剂相比，服用含有绿茶、辣椒素和生姜的膳食补充剂可使体重显著下降（分别为-1.8±1.5千克和+0.4±1.2千克，p<0.001），体重指数（BMI）也显著下降（分别为-0.7±0.5千克/平方米和+0.1±0.5千克/平方米，p<0.001）。此外，与安慰剂相比，同时补充绿茶、辣椒素和生姜提取物的受试者血清胰岛素浓度显著降低（-2.6±3.9与-0.6±2.0微国际单位/毫升，p = 0.02），胰岛素抵抗稳态模型评估值降低（-0.5±0.8与-0.05±0.6，p = 0.01），定量胰岛素敏感性检查指数升高（+0.01±0.01与+0.001±0.01，p = 0.008），血浆谷胱甘肽（GSH）水平升高（+73.8±120.6与-28.3±193.4微摩尔/升，p = 0.03）。