Yilmaz Coşkun Fatma, Elboğa Gülçin, Altunbaş Gökhan, Vuruşkan Ertan, Uğur Berna Kaya, Sucu Murat
Üniversite Bulvarı, Gaziantep Üniversitesi Şahinbey Araştırma ve Uygulama Hastanesi, Department of Cardiology, 27310 Şehitkamil, Gaziantep, Turkey.
Üniversite Bulvarı, Gaziantep Üniversitesi Şahinbey Araştırma ve Uygulama Hastanesi, Department of Psychiatry, 27310 Şehitkamil, Gaziantep, Turkey.
J Electrocardiol. 2018 May-Jun;51(3):440-442. doi: 10.1016/j.jelectrocard.2018.02.003. Epub 2018 Feb 12.
The purpose of this study was to investigate the influence of electrical stimulation transmitted through the body during electroconvulsive therapy on traditional and relatively new ventricular repolarization parameters (Rate corrected QT interval (QTc), QT dispersion (QTd), rate corrected JT interval (JTc), JT dispersion (JTd), T-peak to T-end interval (Tp-e) and Tp-e/QTc ratio) under propofol anaesthesia.
Twenty-two patients (aged 18-50 years) who were each scheduled for ECT for major depression, bipolar disorder or schizophrenia enrolled to the study. Electrocardiography (ECG) recordings were obtained before anaesthesia and within 3-5 min after electrical stimulus of ECT for measurements. QTc, QTd, JTc, JTd, Tp-e and Tp-e/QTc were measured as repolarization indices.
The study included twenty-two patients, 9(40.9%) females and 13(59.1%) males, and the mean age accounted for 33.57 ± 9.95 years. The comparison of the measured parameters before and after ECT, which were not statistically different, were as follows: QTc (416.52 ± 46.64 vs 430.00 ± 34.00msn; p = 0.18), JTc (308.09 ± 25.09 vs 315.47 ± 26.89msn; p = 0.30), QTd (22.27 ± 11.51 vs 20.45 ± 9.9msn; p = 0.52) and JTd (22.72 ± 11.2 vs 17.72 ± 10.20msn; p = 0.06). Also, no significant difference was detected at the following parameters Tp-e (80.0 ± 13.45 vs 78.63 ± 15.21msn; p = 0.65) and Tp-e/QTc ratio (0.19 ± 0.03 vs 0.18 ± 0.07; p = 0.08). On the other hand, HR showed a significant increase after ECT at 88.13 ± 13.74 vs 93.0 ± 15.2 bpm; p = 0.03.
QTc, QTd, JTc, JTd, Tp-e interval and Tp-e/QTc ratio, which are thought to be potential repolarisation markers for ventricular arrhythmias, did not demonstrate significant change within 3-5 min of electrical stimulation during ECT.
本研究旨在探讨在丙泊酚麻醉下，电休克治疗期间经身体传导的电刺激对传统及相对较新的心室复极参数（心率校正QT间期（QTc）、QT离散度（QTd）、心率校正JT间期（JTc）、JT离散度（JTd）、T波峰至T波终末间期（Tp-e）及Tp-e/QTc比值）的影响。
22例年龄在18至50岁之间、因重度抑郁、双相情感障碍或精神分裂症计划接受电休克治疗的患者纳入本研究。在麻醉前及电休克治疗电刺激后3至5分钟内进行心电图（ECG）记录以进行测量。测量QTc、QTd、JTc、JTd、Tp-e及Tp-e/QTc作为复极指标。
本研究纳入22例患者，其中女性9例（40.9%），男性13例（59.1%），平均年龄为33.57±9.95岁。电休克治疗前后测量参数的比较如下：QTc（416.52±46.64 vs 430.00±34.00msn；p = 0.18）、JTc（308.09±25.09 vs 315.47±26.89msn；p = 0.30）、QTd（22.27±11.51 vs 20.45±9.9msn；p = 0.52）及JTd（22.72±11.2 vs 17.72±10.20msn；p = 0.06），差异均无统计学意义。此外，以下参数Tp-e（80.0±13.45 vs 78.63±15.21msn；p = 0.65）及Tp-e/QTc比值（0.19±0.03 vs 0.18±0.07；p = 0.08）也未检测到显著差异。另一方面，心率在电休克治疗后显著增加，分别为88.13±13.74 vs 93.0±15.2次/分；p = 0.03。
被认为是室性心律失常潜在复极标志物的QTc、QTd、JTc、JTd、Tp-e间期及Tp-e/QTc比值，在电休克治疗电刺激后3至5分钟内未显示出显著变化。
