Cretton Sylvian, Oyarzún Alejandra, Righi Davide, Sahib Lamia, Kaiser Marcel, Christen Philippe, Fajardo Victor
a School of Pharmaceutical Sciences , University of Geneva, University of Lausanne , Geneva , Switzerland.
b Faculty of Science , University of Magallanes , Punta Arenas , Chile.
Nat Prod Res. 2018 Mar;32(6):695-701. doi: 10.1080/14786419.2017.1338287. Epub 2017 Jun 8.
A new bibenzyl derivative (4), together with two glycosylated flavonoids (1 and 2), batatasin III (3) and the phenanthrene isohircinol (5) were isolated from the aerial parts of Gavilea lutea. Their structures were elucidated on the basis of spectroscopic studies including 1D and 2D NMR, UV, IR and HRESIMS. All isolated compounds were evaluated for their antifungal activity towards Candida albicans. The new compound 4 showed inhibitory activity with a MIQ of 50 μg. In addition, compound 4 exhibited a selective activity (IC = 2.3 μg/mL) against Leishmania donovani.
从黄花加维列亚（Gavilea lutea）的地上部分分离出一种新的联苄衍生物（4），以及两种糖基化黄酮类化合物（1和2）、甘薯素III（3）和菲类化合物异hircinol（5）。通过包括一维和二维核磁共振、紫外、红外和高分辨电喷雾电离质谱在内的光谱研究确定了它们的结构。对所有分离出的化合物针对白色念珠菌的抗真菌活性进行了评估。新化合物4表现出抑制活性，最低抑菌浓度为50μg。此外，化合物4对杜氏利什曼原虫表现出选择性活性（半数抑制浓度=2.3μg/mL）。
