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新西兰的哮喘死亡率:一项为期两年的全国性研究。

Asthma mortality in New Zealand: a two year national study.

作者信息

Sears M R, Rea H H, Beaglehole R, Gillies A J, Holst P E, O'Donnell T V, Rothwell R P, Sutherland D C

出版信息

N Z Med J. 1985 Apr 24;98(777):271-5.

PMID:2859567
Abstract

The epidemic of deaths from bronchial asthma in New Zealand was investigated by a two-year national review of all deaths of persons under 70 years where "asthma" appeared in part I of a death certificate or in a coroner's report of cause of death. Information about the patients, the characteristics and management of their asthma and the circumstances of the fatal episode was obtained by interviewing relatives and general practitioners and perusal of hospital records. The reviewing panel of the asthma task force of the Medical Research Council considered 271 of the 342 deaths studied were due to asthma. A high national asthma mortality rate (5.1 per 100 000) was confirmed, with rates for Maoris (18.9) and Pacific Islanders (9.4) considerably higher than that for Europeans (3.4 per 100 000). After standardising for age and ethnic groups, there remained a threefold variation in mortality rates among health districts suggesting regional differences in prevalence, severity or management of asthma. No single cause for these high mortality rates was found. One-quarter of the deaths occurred in patients who had had previous life threatening attacks. Excessive use of bronchodilator drugs did not account for the high mortality rates, but inappropriate prolonged use of a home nebuliser may have delayed institution of other therapy in a few cases.

摘要

通过对70岁以下人群的所有死亡病例进行为期两年的全国性回顾调查,研究了新西兰支气管哮喘死亡的流行情况。这些死亡病例的死亡证明第一部分或死因裁判官报告中出现了“哮喘”一词。通过采访亲属和全科医生以及查阅医院记录,获取了有关患者、其哮喘的特征和治疗情况以及致命发作情况的信息。医学研究理事会哮喘特别工作组的审查小组认为,在研究的342例死亡病例中,有271例是由哮喘导致的。确认了较高的全国哮喘死亡率(每10万人中有5.1人),其中毛利人(18.9)和太平洋岛民(9.4)的死亡率远高于欧洲人(每10万人中有3.4人)。在对年龄和种族进行标准化后,各健康区之间的死亡率仍存在三倍的差异,这表明哮喘的患病率、严重程度或治疗在地区上存在差异。未发现导致这些高死亡率的单一原因。四分之一的死亡发生在曾有过危及生命发作的患者身上。支气管扩张剂药物的过度使用并不能解释高死亡率,但在少数情况下,家用雾化器的不当长期使用可能延误了其他治疗的实施。

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