Sears M R
Eur J Respir Dis Suppl. 1986;147:175-81.
Asthma mortality rates have declined only slowly since 1960, and recently have increased in some countries. Deaths in New Zealand's 5-34 year olds showed a sustained increase from 1977 to 1982. In the western United States, asthma mortality in older subjects increased from 1979 to 1982. In 15-44 year olds in England and Wales, mortality rates for females are now lower than in 1960, but rates for males are not. Current asthma mortality rates for Canadian 5-34 year olds are twice those reported a decade ago. A 2-year national study of all New Zealand patients under the age of 70 whose deaths were certified as due to, or related to, asthma found differences in verified asthma mortality rates among races (Maoris 18.9, Pacific Island Polynesians 9.4, and Europeans 3.4 per 100,000); the higher non-European rates explained 36% of the 'excess' New Zealand mortality compared with England. Errors in certification led to a 13% net overestimate of asthma mortality in both countries, but certification was highly accurate in 5-34 year olds. The increase in asthma mortality in the younger age groups is not an artefact of certification or coding, but is real and substantial. Although factors common to previous studies--poor patient compliance, inadequate assessment and therapy, overreliance on bronchodilators and underuse of corticosteroids, and delays in obtaining help--were frequently recognized, no single cause was found to explain the three-fold greater mortality in New Zealand compared with England.(ABSTRACT TRUNCATED AT 250 WORDS)
自1960年以来,哮喘死亡率仅缓慢下降,最近在一些国家还出现了上升。新西兰5至34岁人群的死亡人数在1977年至1982年期间持续增加。在美国西部,老年患者的哮喘死亡率在1979年至1982年期间有所上升。在英格兰和威尔士的15至44岁人群中,女性的死亡率目前低于1960年,但男性并非如此。加拿大5至34岁人群目前的哮喘死亡率是十年前报告的两倍。一项针对新西兰所有70岁以下因哮喘死亡或与哮喘相关死亡的患者进行的为期两年的全国性研究发现,不同种族(毛利人每10万人中有18.9人、太平洋岛波利尼西亚人每10万人中有9.4人、欧洲人每10万人中有3.4人)经核实的哮喘死亡率存在差异;与英格兰相比,非欧洲人较高的死亡率解释了新西兰“超额”死亡率的36%。认证错误导致两国哮喘死亡率净高估13%,但在5至34岁人群中认证非常准确。年轻年龄组哮喘死亡率的上升并非认证或编码的人为因素,而是真实且显著的。尽管先前研究中常见的因素——患者依从性差、评估和治疗不足、过度依赖支气管扩张剂和皮质类固醇使用不足以及获得帮助延迟——经常被认识到,但没有发现单一原因能解释新西兰与英格兰相比高出三倍的死亡率。(摘要截选至250字)