Auranwiwat Chiramet, Wongsomboon Puttandon, Thaima Thanaphat, Rattanajak Roonglawan, Kamchonwongpaisan Sumalee, Willis Anthony C, Lie Wilford, Pyne Stephen G, Limtharakul Née Ritthiwigrom Thunwadee
Department of Chemistry, Faculty of Science, Chiang Mai University, Sutep, Muang, Chiang Mai 50200, Thailand; The Graduate School, Chiang Mai University, Sutep, Muang, Chiang Mai 50200, Thailand.
Department of Chemistry, Faculty of Science, Chiang Mai University, Sutep, Muang, Chiang Mai 50200, Thailand.
Fitoterapia. 2017 Jul;120:103-107. doi: 10.1016/j.fitote.2017.06.002. Epub 2017 Jun 9.
Three new 2-phenylnaphthalene derivatives, cherrevenaphthalenes A-C (1-3), and a new polyoxygenated cyclohexene derivative, (-)-uvaribonol F (4) together with six known compounds, 5-10, were isolated from the stem and root extracts of Uvaria cherrevensis (Annonaceae). The structures of all isolated compounds were elucidated by spectroscopic analysis. The structures of 3 and 4 were further confirmed by single crystal X-ray diffraction methods. Compound 2 exhibited modest antiplasmodial activity against the P. falciparum stains TM4/8.2 and K1CB1 with IC values of 18.8±3.63 and 23.4±4.08μM, respectively, and weak cytotoxicity to a Vero cell line. Furthermore, compound 4 displayed cytotoxic activity against a KB cell line with an IC value of 22.1±0.42μM but was non-cytotoxic to the Vero cell line. Compound 5 revealed stronger cytotoxicity towards the KB cell line, with an IC value of 5.05±0.86μM and was nearly equally cytotoxic to the Vero cell line.
从乌饭叶紫玉盘（番荔枝科）的茎和根提取物中分离出三种新的2-苯基萘衍生物，即紫玉盘萘A-C（1-3），一种新的多氧化环己烯衍生物（-）-紫玉盘醇F（4）以及六种已知化合物5-10。所有分离出的化合物结构均通过光谱分析得以阐明。3和4的结构通过单晶X射线衍射方法进一步得到证实。化合物2对恶性疟原虫株TM4/8.2和K1CB1表现出适度的抗疟活性，IC值分别为18.8±3.63和23.4±4.08μM，并且对Vero细胞系具有较弱的细胞毒性。此外，化合物4对KB细胞系表现出细胞毒性活性，IC值为22.1±0.42μM，但对Vero细胞系无细胞毒性。化合物5对KB细胞系显示出更强的细胞毒性，IC值为5.05±0.86μM，并且对Vero细胞系的细胞毒性几乎相同。
