Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Sutep, Muang, Chiang Mai 50200, Thailand; The Graduate School, Chiang Mai University, Chiang Mai 50200, Thailand; School of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia.
Medical Molecular Biology Research Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Thailand Science Park, Pathumthani 12120, Thailand.
Fitoterapia. 2018 Oct;130:198-202. doi: 10.1016/j.fitote.2018.08.020. Epub 2018 Aug 27.
The phytochemical investigation of the fruit extracts of Uvaria cherrevensis led to the isolation and characterization of four new C-benzyl flavonoids; cherrevenones A-D (1-4) together with 11 known compounds. The isolated compounds were characterized using spectroscopic techniques. Compounds 1, 3, 5 and 11 showed moderate inhibitory activities against the P. falciparum strains TM4/8.2 and K1CB1 with IC values ranging from 21.0 ± 3.10 - 33.7 ± 7.69 and 21.0 ± 5.44 - 43.5 ± 11.9 μM, respectively. Compounds 1, 2, 5, 10 and 11 exhibited strong cytotoxic activities against KB cells with IC values ranging from 0.60 ± 0.17 - 4.91 ± 2.69 μM which were similar to their cytotoxic activities found against Vero cells, except for compound 5, which was non-toxic to Vero cells.
对乌饭树果实提取物的植物化学研究导致了四个新的 C-苄基黄酮类化合物的分离和鉴定; 切雷文酮 A-D（1-4）以及 11 种已知化合物。使用光谱技术对分离得到的化合物进行了表征。化合物 1、3、5 和 11 对 TM4/8.2 和 K1CB1 两种疟原虫株表现出中等抑制活性，IC 值范围为 21.0±3.10-33.7±7.69 和 21.0±5.44-43.5±11.9 μM。化合物 1、2、5、10 和 11 对 KB 细胞表现出强烈的细胞毒性活性，IC 值范围为 0.60±0.17-4.91±2.69 μM，与它们对 Vero 细胞的细胞毒性活性相似，除了化合物 5，它对 Vero 细胞没有毒性。
