从Cherrevensis 猪殃殃的根中提取的抗疟多氧化环己烯衍生物。
Antimalarial polyoxygenated cyclohexene derivatives from the roots of Uvaria cherrevensis.
机构信息
Natural Products Research Unit, Department of Chemistry and Center of excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Natural Products Research Unit, Department of Chemistry and Center of excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
出版信息
Fitoterapia. 2018 Jun;127:420-424. doi: 10.1016/j.fitote.2018.01.018. Epub 2018 Feb 15.
Three new polyoxygenated cyclohexene derivatives named cherrevenisyls A and B (1 and 2), and ellipeiopsol E (3), along with fifteen known compounds, were isolated from the roots of Uvaria cherrevensis. Their structures were determined by spectroscopic methods including 2D NMR techniques and mass spectrometry. The absolute configurations of 1 and 2 were assigned. Compounds 1, 2 and 5 showed antimalarial activity against Plasmodium falciparum with IC ranging from 3.34-7.34μg/mL. Compounds 5-18 exhibited cytotoxicity against three cancer cell lines (KB, MCF-7 and NCI-H187) with IC values in ranging from 1.26-49.03μg/mL.
从鸡矢藤(Uvaria cherrevensis)的根部分离得到三个新的多氧化环己烯衍生物，命名为 cherrevenisyls A 和 B(1 和 2)，以及 ellipeiopsol E(3)，以及十五个已知化合物。通过包括 2D NMR 技术和质谱在内的光谱方法确定了它们的结构。确定了 1 和 2 的绝对构型。化合物 1、2 和 5 对恶性疟原虫(Plasmodium falciparum)表现出抗疟活性，IC 范围为 3.34-7.34μg/mL。化合物 5-18 对三种癌细胞系(KB、MCF-7 和 NCI-H187)表现出细胞毒性，IC 值范围为 1.26-49.03μg/mL。
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