Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Giovanni Lorenzini Medical Science Foundation, Milan, Italy and Houston, TX.
Sex Med Rev. 2017 Jul;5(3):349-364. doi: 10.1016/j.sxmr.2017.04.002. Epub 2017 Jun 7.
Complex non-communicable diseases (NCDs), including cancer, cardiovascular disease, obesity, diabetes, and chronic respiratory disorders, are major causes of morbidity and mortality globally. The complexity of NCDs requires innovative, integrated, and interdisciplinary approaches for diagnosis, treatment, and prevention by adopting the new paradigm called systems medicine. A growing body of evidence suggests that sexual dysfunction in general and erectile and lubrication dysfunctions in particular are, in a sex-dependent manner, efficient predictors of overall systemic well-being. However, the relation between systems medicine and sexual medicine is not well defined.
To demonstrate that in combating the major NCDs, sexual health can be used as a surrogate marker of systemic health and can facilitate the diagnosis, treatment, and prevention of NCDs.
A comprehensive review of peer-reviewed publications on the topic was performed through a PubMed search.
Because there is a strong biological basis for the developmental origins of health and disease not only in the early phases of development but also later in life, the identification of appropriate biomarkers is essential for monitoring these timelines and trajectories for better understanding NCD processes, risk stratification for NCD intervention, and prevention.
In this review, I propose a novel approach in which sexual medicine can be used as a new tool to understand and manage NCDs and as a marker of systemic health. Moreover, the multipronged application of systems medicine to pathophysiologic changes leading to sexual dysfunction might sustain the growth of a young science such as sexual medicine.
This multilevel approach has the potential to suggest novel avenues for the comprehensive management of NCDs and sexual dysfunction in a sex-dependent manner. Jannini EA. SM = SM: The Interface of Systems Medicine and Sexual Medicine for Facing Non-Communicable Diseases in a Gender-Dependent Manner. Sex Med Rev 2017;5:349-364.
复杂的非传染性疾病（NCDs），包括癌症、心血管疾病、肥胖、糖尿病和慢性呼吸道疾病，是全球发病率和死亡率的主要原因。NCD 的复杂性需要通过采用新的系统医学范式，创新、综合和跨学科的方法来进行诊断、治疗和预防。越来越多的证据表明，一般性功能障碍，特别是勃起和润滑功能障碍，以性别依赖的方式，是整体全身健康的有效预测指标。然而，系统医学和性医学之间的关系尚未得到很好的定义。
证明在对抗主要的 NCD 时，性健康可以作为全身健康的替代标志物，并有助于 NCD 的诊断、治疗和预防。
通过 PubMed 搜索对该主题的同行评议出版物进行了全面审查。
由于健康和疾病的发育起源不仅在发育的早期阶段，而且在生命的后期都有很强的生物学基础，因此确定适当的生物标志物对于监测这些时间线和轨迹以更好地了解 NCD 过程、对 NCD 干预进行风险分层以及预防非常重要。
在这篇综述中，我提出了一种新的方法，即性医学可以用作理解和管理 NCD 以及作为全身健康标志物的新工具。此外，系统医学在导致性功能障碍的病理生理变化中的多方面应用可能会支持性医学等年轻科学的发展。
这种多层次的方法有可能以性别依赖的方式为全面管理 NCD 和性功能障碍提供新的途径。
