Xu Rui, Luo Runlan, Tan Bijun, Gan Tian, Li Guangsen
a Department of Ultrasound , the Second Affiliated Hospital of Dalian Medical University , China.
Acta Cardiol. 2017 Feb;72(1):28-35. doi: 10.1080/00015385.2017.1281548.
Background Chronic excessive alcohol intake has been reported as a possible cause of dilated cardiomyopathy. Two-dimensional speckle-tracking echocardiography (2D-STE) is a novel method for the angle-independent and objective quantification of myocardial deformation. This study sought to assess left atrial function changes among alcoholics related to the duration of heavy drinking by 2D-STE. Methods We classified 92 asymptomatic alcoholics into mild, moderate and severe groups. Thirty age-matched controls were also recruited. We measured left atrial (LA) phasic volumes (max, min and pre-atrial contraction volume) using Simpson's method in apical four-chamber view. Passive emptying (LAPEF) and active emptying (LAAEF) indices were calculated. Global longitudinal strain rate (SRs) during left ventricular (LV) ejection, early diastolic strain rate (SRe) during LV early diastole and peak negative strain rate (SRa) after the P-wave were also obtained by averaging all atrial segments. Results The alcoholics had larger LA volumes (max, min and pre-atrial contraction volume) since moderate stage (P < 0.01). LAPEF, SRs SRe, and E/A ratio showed progressive decrease according to the grades of alcoholism. The differences between the groups were significant, beginning from the moderate group (P < 0.01). During LAAEF, SRa values increased with the disease severity up to moderate alcoholics and then deteriorated significantly in severe alcoholics (P < 0.01). Conclusions These data suggest that 2D-STE may be considered a promising tool for the early detection of impairment of LA function in alcoholics.
慢性过量饮酒已被报道为扩张型心肌病的一个可能病因。二维斑点追踪超声心动图（2D-STE）是一种用于心肌变形角度独立且客观量化的新方法。本研究旨在通过2D-STE评估与重度饮酒持续时间相关的酗酒者左心房功能变化。方法：我们将92名无症状酗酒者分为轻度、中度和重度组。还招募了30名年龄匹配的对照组。我们在心尖四腔视图中使用辛普森法测量左心房（LA）的阶段性容积（最大、最小和心房收缩前容积）。计算被动排空（LAPEF）和主动排空（LAAEF）指数。通过对所有心房节段求平均值，还获得了左心室（LV）射血期间的整体纵向应变率（SRs）、LV舒张早期的早期舒张应变率（SRe）以及P波后的峰值负应变率（SRa）。结果：自中度阶段起，酗酒者的LA容积（最大、最小和心房收缩前容积）更大（P < 0.01）。LAPEF、SRs、SRe和E/A比值根据酗酒程度呈逐渐下降趋势。从中度组开始，各组之间的差异具有统计学意义（P < 0.01）。在LAAEF期间，SRa值随着疾病严重程度增加，直至中度酗酒者，然后在重度酗酒者中显著恶化（P < 0.01）。结论：这些数据表明，2D-STE可被视为早期检测酗酒者LA功能损害的一种有前景的工具。
