Froelicher V, Sullivan M, Myers J, Jensen D
Am J Cardiol. 1985 Apr 26;55(10):155D-161D. doi: 10.1016/0002-9149(85)91073-2.
Fifty-nine male volunteers with stable coronary artery disease underwent 1 year of supervised exercise and were compared with 69 similar control patients. Both groups underwent exercise tests initially and at 1 year to determine maximal oxygen uptake. Initial and 1-year tests were performed with patients off all cardiac medications including beta blockers. Although patients had been randomized to exercise intervention, administration of beta blockers was at the prerogative of their physicians. Thirty-seven percent of the trained group and 39% of the control group were taking beta blockers during the year of study. Regardless of whether or not beta blockers were administered, patients in the exercise intervention group had a significant increase in aerobic capacity and improvement in the other hemodynamic markers of training compared with control subjects. Of the trained patients, those on beta blockers were able to comply with the exercise regimen as well as those not taking beta blockers.
59名患有稳定型冠状动脉疾病的男性志愿者接受了为期1年的监督运动，并与69名类似的对照患者进行了比较。两组患者最初和1年后都进行了运动测试，以确定最大摄氧量。最初和1年时的测试是在患者停用所有心脏药物（包括β受体阻滞剂）的情况下进行的。尽管患者已被随机分配到运动干预组，但β受体阻滞剂的使用由其医生决定。在研究的一年中，37%的训练组和39%的对照组服用了β受体阻滞剂。无论是否使用β受体阻滞剂，与对照组相比，运动干预组患者的有氧能力显著提高，其他训练的血流动力学指标也有所改善。在接受训练的患者中，服用β受体阻滞剂的患者与未服用β受体阻滞剂的患者一样能够遵守运动方案。
