Berk T, Gordon S J, Choi H Y, Cooper H S
Am J Gastroenterol. 1985 May;80(5):355-60.
An exacerbation of idiopathic inflammatory bowel disease associated with the appearance of cytomegalovirus nuclear inclusion bodies in the colon was observed in two patients. In one, improvement in the colitis after withdrawal of corticosteroids suggested cytomegalovirus as the cause of the exacerbation. A review of the 16 reported cases of inflammatory bowel disease with cytomegalovirus superinfection of the colon indicates a high mortality rate (seven of 16), a frequent association with toxic dilatation of the colon, and a clinical course sufficiently severe to require colectomy in 10 of 16 patients. For exacerbations of inflammatory bowel disease associated with evidence of cytomegalovirus infection of the colon which are refractory to medical management withdrawal of corticosteroids and other immunosuppressive therapy should be considered. If necessary, early colectomy may be an appropriate alternative.
在两名患者中观察到特发性炎症性肠病的加重与结肠中巨细胞病毒核内包涵体的出现有关。其中一名患者在停用皮质类固醇后结肠炎有所改善，提示巨细胞病毒是加重的原因。对16例报告的结肠巨细胞病毒重叠感染的炎症性肠病病例进行回顾发现，死亡率很高（16例中有7例），经常与结肠中毒性扩张相关，并且临床病程严重到16例患者中有10例需要进行结肠切除术。对于与结肠巨细胞病毒感染证据相关的炎症性肠病加重，如果药物治疗无效，应考虑停用皮质类固醇和其他免疫抑制疗法。如有必要，早期结肠切除术可能是一种合适的选择。
