Dong Hui-Ming, Huang Jian-Kang, Gong Xiao-Meng, Tao Yi-Sheng
Department of Surgical Oncology, the First Affiliated Hospital of Bengbu Medical College,Bengbu 233003,China.
Department of Pathology, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233003,China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 Sep;47(5):732-737.
To investigate the protein expressions of metastasis-associated in colon cancer 1 (MACC1), KISS-1 (a cancer ruppressor gene) and Snail (the marker of epithelial-mesenchymal transition) in infiltrating breast carcinoma (IBC) and explore the role of them in invasion, metastasis and prognosis in IBC.
Expressions of MACC1, Snail and KISS-1 were examined by immunohistochemistry in 250 specimens of IBC and 80 specimens of normal breast tissues. Their clinicopathological features were analyzed, and their influence on patients' survival was identified.
The positive rate of MACC1, Snail and KISS-1 in normal breast tissues and IBC tissues was 7.5%, 5.0%, 87.5% and 63.6%, 58.8%, 38.0%, respectively. And there was a significant difference between the IBC group and control group ( <0.05). The positive expressions of MACC1, Snail and KISS-1 were significantly different in different TNM stages, lymph node metastasis, types and grades of tumor ( <0.05). The survival time of positive KISS-1 group was significantly longer than that of negative group ( <0.001); the survival time was significantly shorter in positive MACC1 group or Snail group than that of negative groups (both <0.001). Cox regression analysis indicated that the positive expressions of MACC1, Snail and negative expression of KISS-1 were independent risk factors of IBC (<0.05).
Abnormal expression of MACC1, Snail and KISS-1 should be involved in the invasion and metastasis of IBC. The combined detection in the expressions of MACC1, Snail and KISS-1 at the early stage may play an important role in predicting the progression and prognosis of IBC.
研究结肠癌转移相关蛋白1（MACC1）、KISS-1（一种抑癌基因）和Snail（上皮-间质转化标志物）在浸润性乳腺癌（IBC）中的蛋白表达情况，并探讨它们在IBC侵袭、转移及预后中的作用。
采用免疫组织化学法检测250例IBC标本和80例正常乳腺组织标本中MACC1、Snail和KISS-1的表达情况。分析其临床病理特征，并确定它们对患者生存的影响。
正常乳腺组织和IBC组织中MACC1、Snail和KISS-1的阳性率分别为7.5%、5.0%、87.5%和63.6%、58.8%、38.0%。IBC组与对照组之间差异有统计学意义（<0.05）。MACC1、Snail和KISS-1的阳性表达在不同TNM分期、淋巴结转移、肿瘤类型及分级中差异有统计学意义（<0.05）。KISS-1阳性组的生存时间显著长于阴性组（<0.001）；MACC1阳性组或Snail阳性组的生存时间显著短于阴性组（均<0.001）。Cox回归分析表明，MACC1、Snail的阳性表达及KISS-1的阴性表达是IBC的独立危险因素（<0.05）。
MACC1、Snail和KISS-1的异常表达可能参与了IBC的侵袭和转移。早期联合检测MACC1、Snail和KISS-1的表达可能对预测IBC的进展及预后具有重要作用。
