Anand C V, Anand U, Sadasivudu B
Biochem Int. 1985 Feb;10(2):311-7.
Adenosine is a local hormone and is considered to act as a vasodilatory substance when released locally. Alcohol is known to affect membrane structure and acts as a coronary vasodilator. Membrane enzymes such as 5'-nucleotidase, adenosine deaminase, and gammaglutamyl transpeptidase, along with AMP deaminase, have been studied in rat myocardial tissue following the administration of a sufficiently toxic dose (producing semiconsciousness) of ethanol (1ml of 7M ethanol/100g body wt.). The activity of 5'-nucleotidase as well as that of adenosine deaminase increased due to the administration of ethanol, without any significant change in the activities of gammaglutamyl transpeptidase and AMP deaminase. These changes are discussed in relation to the metabolic changes occurring in the myocardium and the resultant effects on the coronary vessels.
腺苷是一种局部激素，在局部释放时被认为是一种血管舒张物质。已知酒精会影响膜结构，并作为冠状动脉扩张剂起作用。在给予大鼠足够毒性剂量（导致半昏迷）的乙醇（1ml 7M乙醇/100g体重）后，对大鼠心肌组织中的膜酶如5'-核苷酸酶、腺苷脱氨酶、γ-谷氨酰转肽酶以及AMP脱氨酶进行了研究。由于给予乙醇，5'-核苷酸酶和腺苷脱氨酶的活性增加，而γ-谷氨酰转肽酶和AMP脱氨酶的活性没有任何显著变化。结合心肌中发生的代谢变化以及对冠状动脉的最终影响对这些变化进行了讨论。
