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青少年和青年的HIV暴露前预防

HIV preexposure prophylaxis for adolescents and young adults.

作者信息

Allen Emily, Gordon Allegra, Krakower Douglas, Hsu Katherine

机构信息

aDivision of Adolescent/Young Adult Medicine, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School bFenway Health, The Fenway Institute cDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School dDivision of STD Prevention and HIV/AIDS Surveillance, Massachusetts Department of Public Health, Jamaica Plain eSection of Pediatric Infectious Diseases, Department of Pediatrics, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts, USA.

出版信息

Curr Opin Pediatr. 2017 Aug;29(4):399-406. doi: 10.1097/MOP.0000000000000512.

DOI:10.1097/MOP.0000000000000512
PMID:28598901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5762125/
Abstract

PURPOSE OF REVIEW

The review describes the evidence for HIV preexposure prophylaxis (PrEP) with daily combined tenofovir disoproxil fumarate and emtricitabine for adolescents and young adults. Current recommendations are described, as are the unique medical, socioeconomic, and legal considerations regarding the use of PrEP for youth.

RECENT FINDINGS

PrEP with daily oral tenofovir disoproxil fumarate-emtricitabine has been shown to help prevent new HIV infection among adults at substantial risk. Evidence suggests a protective benefit of PrEP for youth at risk for HIV, although low adherence is emerging as a barrier to effective use.

SUMMARY

Effective use of antiretrovirals for PrEP represents a seminal development in HIV prevention efforts. Improving access and adherence to PrEP for youth has the potential to substantially reduce the incidence of HIV in this population.

摘要

综述目的

本综述阐述了青少年和青年每日联合服用替诺福韦酯富马酸盐和恩曲他滨进行HIV暴露前预防（PrEP）的证据。文中描述了当前的建议，以及关于青少年使用PrEP的独特医学、社会经济和法律考量。

最新发现

每日口服替诺福韦酯富马酸盐-恩曲他滨进行PrEP已被证明有助于预防有高感染风险的成年人感染新的HIV。有证据表明PrEP对有HIV感染风险的青少年有保护作用，尽管低依从性正成为有效使用PrEP的障碍。

总结

有效使用抗逆转录病毒药物进行PrEP是HIV预防工作中的一项重大进展。改善青少年获取PrEP的途径并提高其依从性，有可能大幅降低该人群中HIV的发病率。