Islam Rakibul M, Oldroyd John, Karim Md Nazmul, Hossain Sultana Monira, Md Emdadul Hoque Dewan, Romero Lorena, Fisher Jane
Department of Population Sciences, University of Dhaka, Dhaka, Bangladesh.
Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
BMJ Open. 2017 Jun 8;7(6):e015626. doi: 10.1136/bmjopen-2016-015626.
Pelvic floor disorders (PFDs) including urinary incontinence, faecal incontinence and pelvic organ prolapse are common debilitating conditions among women in high-income countries. However, PFDs in women in low/middle-income countries (LMICs) have not been studied extensively. We aim to conduct a systematic review and meta-analysis of the available literature to determine the prevalence of, and/or risk factors for, PFDs in women in LMIC.
We will search electronic databases including MEDLINE, EMBASE, PsycINFO, CINAHL, Maternity & Infant Care and Google Scholar for eligible studies. Inclusion criteria will be observational studies of healthy women, which have collected data using validated or non-validated tools, are published in English and were conducted in community women in LMICs, defined by the World Bank. A standardised data extraction form will be developed and piloted, based on the template of the Cochrane good practice data extraction form. All included studies will be assessed based on a risk-of-bias tool specifically developed for prevalence studies. Pooled prevalence estimates of PFDs will be generated using RevMan V.5.2.1 software. Forest plots will be generated to display the overall random-effects pooled estimates with CIs. A metaregression will be conducted to identify sources of between-study heterogeneity in the pooled prevalence estimates. We will quantify heterogeneity using the I measure and its CI. We will use funnel plots to detect potential reporting biases and small-study effects. We will also conduct a sensitivity analysis to verify the robustness of the study conclusions, assessing the impact of methodological quality, study design, sample size and the effect of missing data.
Our review is entirely based on published data. Thus, an ethics committee approval or written informed consent will not be required for this study as primary data will not be collected. The results will be disseminated by publication of the manuscript in a peer-reviewed journal and/or will be presented at relevant conferences.
CRD42016043881.
包括尿失禁、粪失禁和盆腔器官脱垂在内的盆底功能障碍（PFDs）是高收入国家女性中常见的使人衰弱的疾病。然而，低收入/中等收入国家（LMICs）女性的盆底功能障碍尚未得到广泛研究。我们旨在对现有文献进行系统综述和荟萃分析，以确定低收入/中等收入国家女性盆底功能障碍的患病率和/或危险因素。
我们将检索电子数据库，包括MEDLINE、EMBASE、PsycINFO、CINAHL、母婴护理数据库和谷歌学术，以查找符合条件的研究。纳入标准将是针对健康女性的观察性研究，这些研究使用经过验证或未经验证的工具收集数据，以英文发表，并在世界银行定义的低收入/中等收入国家的社区女性中进行。将根据Cochrane良好实践数据提取表的模板开发并试用标准化数据提取表。所有纳入研究将根据专门为患病率研究开发的偏倚风险工具进行评估。将使用RevMan V.5.2.1软件生成盆底功能障碍的合并患病率估计值。将生成森林图以显示带有置信区间的总体随机效应合并估计值。将进行元回归以确定合并患病率估计值中研究间异质性的来源。我们将使用I统计量及其置信区间来量化异质性。我们将使用漏斗图来检测潜在的报告偏倚和小研究效应。我们还将进行敏感性分析，以验证研究结论的稳健性，评估方法质量、研究设计、样本量和缺失数据的影响。
我们的综述完全基于已发表的数据。因此，本研究无需伦理委员会批准或书面知情同意，因为不会收集原始数据。研究结果将通过在同行评审期刊上发表手稿进行传播和/或将在相关会议上展示。
PROSPERO注册号：CRD42016043881。
