男性夜间工作与前列腺癌：一项瑞典前瞻性队列研究。
Night work and prostate cancer in men: a Swedish prospective cohort study.
作者信息
Åkerstedt Torbjrn, Narusyte Jurgita, Svedberg Pia, Kecklund Göran, Alexanderson Kristina
机构信息
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Stress Research Institute, Stockholm University, Stockholm, Sweden.
出版信息
BMJ Open. 2017 Jun 8;7(6):e015751. doi: 10.1136/bmjopen-2016-015751.
OBJECTIVES
Prostate cancer is the most common cancer and the second leading cause of cancer-related deaths among men, but the contributing factors are unclear. One such may be night work because of the day/night alternation of work and the resulting disturbance of the circadian system. The purpose of the present study was to investigate the prospective relation between number of years with night work and prostate cancer in men.
DESIGN
Cohort study comparing night and day working twins with respect to incident prostate cancer in 12 322 men.
SETTING
Individuals in the Swedish Twin Registry.
PARTICIPANTS
12 322 male twins.
OUTCOME MEASURES
Prostate cancer diagnoses obtained from the Swedish Cancer Registry with a follow-up time of 12 years, with a total number of cases=454.
RESULTS
Multiple Cox proportional hazard regression analysis, adjusted for a number of covariates, showed no association between ever night work and prostate cancer, nor for duration of night work and prostate cancer. Analysis of twin pairs discordant for prostate cancer (n=332) showed no significant association between night work and prostate cancer.
CONCLUSIONS
The results, together with previous studies, suggest that night work does not seem to constitute a risk factor for prostate cancer.
目的
前列腺癌是男性中最常见的癌症，也是癌症相关死亡的第二大原因，但促成因素尚不清楚。其中一个因素可能是夜班工作，因为工作的昼夜交替以及由此导致的昼夜节律系统紊乱。本研究的目的是调查男性夜班工作年限与前列腺癌之间的前瞻性关系。
设计
队列研究，比较12322名男性中从事夜班和白班工作的双胞胎的前列腺癌发病情况。
地点
瑞典双胞胎登记处的个体。
参与者
12322对男性双胞胎。
观察指标
从瑞典癌症登记处获得前列腺癌诊断信息，随访时间为12年，病例总数为454例。
结果
多因素Cox比例风险回归分析在调整了多个协变量后显示，既往夜班工作与前列腺癌之间无关联，夜班工作时长与前列腺癌之间也无关联。对前列腺癌不一致的双胞胎对（n = 332）进行分析，结果显示夜班工作与前列腺癌之间无显著关联。
结论
这些结果与先前的研究共同表明，夜班工作似乎不构成前列腺癌的危险因素。
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