Park Sungkyun, Ma Seongwon, Seo Hoekyeong, Lee Sang Gil, Lee Jihye, Ye Shinhee
Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Ulsan, Korea.
Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Incheon, Korea.
Ann Occup Environ Med. 2023 Dec 7;35:e52. doi: 10.35371/aoem.2023.35.e52. eCollection 2023.
In 2019, the International Agency for Research on Cancer re-evaluated the carcinogenicity of night-shift work and reported that there is limited evidence that night-shift work is carcinogenic for the development of prostate cancer. Therefore, in 2020 and 2021, the Korean Epidemiologic Investigation Evaluation Committee concluded that 2 cases of prostate cancer were occupational diseases related to the night-shift work. Here, we report the 2 cases of prostate cancer in night-shift workers which were first concluded as occupational diseases by the Korean Epidemiologic Investigation Evaluation Committee.
Patient A: A 61-year-old man worked as a city bus driver for approximately 17 years, from 2002 to 2019, and was exposed to night-shift work during this period. In March 2017, the patient was diagnosed with high-grade prostate cancer through core-needle biopsy after experiencing stinging pain lasting for 2 months. Patient B: A 56-year-old man worked as an electrician and an automated equipment operator in a cement manufacturing plant for 35 years from 1976 to 2013 and was exposed to night-shift work during this period. In 2013, the patient was diagnosed with high-grade prostate cancer through core needle biopsy at a university hospital because of dysuria that lasted for 6 months.
The 2 workers were diagnosed with high-grade prostate cancer after working night shifts for 17 and 35 years respectively. Additionally, previous studies have reported that high-grade prostate cancer has a stronger relationship with night-shift work than low or medium-grade prostate cancer. Therefore, the Korean Epidemiologic Investigation Evaluation Committee concluded that night-shift work in these 2 patients contributed to the development of their prostate cancer.
2019年，国际癌症研究机构重新评估了夜班工作的致癌性，并报告称，仅有有限的证据表明夜班工作会导致前列腺癌。因此，在2020年和2021年，韩国流行病学调查评估委员会认定2例前列腺癌为与夜班工作相关的职业病。在此，我们报告2例夜班工作者患前列腺癌的病例，这2例病例最初被韩国流行病学调查评估委员会认定为职业病。
患者A：一名61岁男性，从2002年至2019年担任城市公交司机约17年，在此期间从事夜班工作。2017年3月，患者在经历持续2个月的刺痛后，通过穿刺活检被诊断为高级别前列腺癌。患者B：一名56岁男性，从1976年至2013年在一家水泥厂担任电工和自动化设备操作员35年，在此期间从事夜班工作。2013年，患者因持续6个月的排尿困难，在一家大学医院通过穿刺活检被诊断为高级别前列腺癌。
这2名工人分别在从事夜班工作17年和35年后被诊断为高级别前列腺癌。此外，既往研究报告称，与低级别或中级别前列腺癌相比，高级别前列腺癌与夜班工作的关系更为密切。因此，韩国流行病学调查评估委员会认定，这2例患者的夜班工作促使了前列腺癌的发生。
