Koda A, Nakatomi I, Nakamura K, Inoue H, Kamimura T
Int J Immunopharmacol. 1985;7(1):41-9. doi: 10.1016/0192-0561(85)90007-4.
A newly synthesized compound, cis-1-methyl-4-isohexylcyclohexane carboxylic acid (IG-10), has been reported as an inhibitor of delayed hypersensitivity reaction. In the present paper, the mechanisms regarding the inhibitory action of IG-10 was investigated on delayed hypersensitivity reactions. p-Phenylenediamine-induced contact dermatitis in guinea pigs was significantly inhibited when the drug was given in a dose of 100 mg/kg p.o. at various times after challenge with the antigen. IG-10 inhibited both contact dermatitis and monocytes or neutrophils infiltrations induced by picryl chloride in mice. A skin reaction, similar to that seen in the case of delayed hypersensitivity reaction, was induced by an intradermal injection of phytohemagglutinin-P (PHA-P) stimulated lymphocytes in guinea pigs. This reaction was a useful method for assessing the effect of drugs on the release of lymphokines, particularly skin reactive factor (SRF). IG-10 in a concentration of 10(-5) g/ml inhibited the release of SRF as well as the release of migration inhibitory factor (MIF) from guinea pig lymphocytes stimulated by PHA-P. The reduction of delta 4-3-ketone of aldosterone and/or hydrocortisone by rat liver homogenates was not affected with IG-10, unlike that seen in the case of glycyrrhizin.
一种新合成的化合物，顺式-1-甲基-4-异己基环己烷羧酸（IG-10），已被报道为迟发型超敏反应的抑制剂。在本文中，研究了IG-10对迟发型超敏反应的抑制作用机制。在用抗原攻击后的不同时间，以100mg/kg的口服剂量给予该药物时，对苯二胺诱导的豚鼠接触性皮炎有显著抑制作用。IG-10抑制了小鼠中由苦味酸诱导的接触性皮炎以及单核细胞或中性粒细胞浸润。通过在豚鼠皮内注射植物血凝素-P（PHA-P）刺激的淋巴细胞，诱导出一种类似于迟发型超敏反应的皮肤反应。这种反应是评估药物对淋巴因子释放，特别是皮肤反应因子（SRF）释放影响的一种有用方法。浓度为10(-5)g/ml的IG-10抑制了由PHA-P刺激的豚鼠淋巴细胞释放SRF以及迁移抑制因子（MIF）。与甘草酸的情况不同，大鼠肝匀浆对醛固酮和/或氢化可的松的△4-3-酮还原作用不受IG-10影响。
