Zhou Yu, Li Hui, Siddiqui Nausheen, Caudle Yi, Zhang Haiju, Elgazzar Mohamed, Yin Deling
Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Department of Internal Medicine, College of Medicine, East Tennessee State University, Johnson City, TN 37614, United States.
J Neuroimmunol. 2017 Aug 15;309:72-76. doi: 10.1016/j.jneuroim.2017.05.014. Epub 2017 May 22.
Physical or psychological chronic stress can suppress the immune system. However, the mechanisms remain to be elucidated. We investigated the effect of hematopoietic stem-progenitor cells (HSPCs) on chronic stress-induced the alterations of immune responses. We demonstrate that HSPCs prevents stress-induced lymphocyte apoptosis. Moreover, we also demonstrate that the protective effect of HSPCs on stress-induced lymphocyte reduction exerts by steroid hormones. Furthermore, we reveal that chronic stress-induced T cell-mediated immune responses contributes to the protective effect of HSPCs. These results indicate that HPSCs might offer a novel therapeutic strategy against the deleterious effects of chronic stress on the immune system.
身体或心理上的慢性应激会抑制免疫系统。然而，其机制仍有待阐明。我们研究了造血干祖细胞（HSPCs）对慢性应激诱导的免疫反应改变的影响。我们证明HSPCs可预防应激诱导的淋巴细胞凋亡。此外，我们还证明HSPCs对应激诱导的淋巴细胞减少的保护作用是由类固醇激素发挥的。此外，我们揭示慢性应激诱导的T细胞介导的免疫反应有助于HSPCs的保护作用。这些结果表明，造血干细胞可能为对抗慢性应激对免疫系统的有害影响提供一种新的治疗策略。
