Fischer Kimberly D, Agrawal Devendra K
Department of Medical Microbiology and Immunology, Creighton University School of Medicine , Omaha, NE , USA.
Department of Medical Microbiology and Immunology, Creighton University School of Medicine , Omaha, NE , USA ; Department of Biomedical Sciences, Creighton University School of Medicine , Omaha, NE , USA ; Department of Internal Medicine, Creighton University School of Medicine , Omaha, NE , USA ; Center for Clinical and Translational Science, Creighton University School of Medicine , Omaha, NE , USA.
Front Immunol. 2013 Dec 4;4:428. doi: 10.3389/fimmu.2013.00428.
Hematopoietic stem and progenitor cells contribute to allergic inflammation. Pro-inflammatory cytokines that are generated following allergen challenge can impact the differentiation of hematopoietic progenitor cells leading to increased production of effector cells such as eosinophils and basophils, which are key cells involved in the pathogenesis of allergic airway inflammation. Homing of stem cells to the lungs is associated with inflammatory and remodeling changes in asthmatics. Factors that modulate the differentiation and increased migration of stem cells to the site of inflammation in asthma remain to be defined. Stem cells can mature at the site of inflammation in response to inflammatory mediators and other components in the milieu. While the available data suggest that hematopoietic cells traffic to target tissues, the molecular factors underlying in situ differentiation have yet to be specified. Here, we critically evaluate the potential role of hematopoietic progenitors in contributing to the increased immune cell infiltrate in allergic asthma and the factors that drive their differentiation.
造血干细胞和祖细胞参与过敏性炎症。过敏原激发后产生的促炎细胞因子可影响造血祖细胞的分化，导致效应细胞如嗜酸性粒细胞和嗜碱性粒细胞的产生增加，这些细胞是过敏性气道炎症发病机制中的关键细胞。干细胞归巢至肺部与哮喘患者的炎症和重塑变化有关。调节干细胞在哮喘中分化和增加向炎症部位迁移的因素仍有待确定。干细胞可在炎症部位因应炎症介质和周围环境中的其他成分而成熟。虽然现有数据表明造血细胞可迁移至靶组织，但原位分化的分子因素尚未明确。在此，我们严格评估造血祖细胞在过敏性哮喘中导致免疫细胞浸润增加所起的潜在作用以及驱动其分化的因素。
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