Nesper Peter L, Soetikno Brian T, Zhang Hao F, Fawzi Amani A
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 440, Chicago, IL 60611, USA.
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N. Michigan Avenue, Suite 440, Chicago, IL 60611, USA; Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA; Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA.
Vision Res. 2017 Oct;139:191-203. doi: 10.1016/j.visres.2017.05.006. Epub 2017 Jun 21.
In recent years, advances in optical coherence tomography (OCT) techniques have increased our understanding of diabetic retinopathy, an important microvascular complication of diabetes. OCT angiography is a non-invasive method that visualizes the retinal vasculature by detecting motion contrast from flowing blood. Visible-light OCT shows promise as a novel technique for quantifying retinal hypoxia by measuring the retinal oxygen delivery and metabolic rates. In this article, we discuss recent insights provided by these techniques into the vascular pathophysiology of diabetic retinopathy. The next milestones for these modalities are large multicenter studies to establish consensus on the most reliable and consistent outcome parameters to study diabetic retinopathy.
近年来，光学相干断层扫描（OCT）技术的进步加深了我们对糖尿病视网膜病变（糖尿病一种重要的微血管并发症）的认识。OCT血管造影是一种非侵入性方法，通过检测流动血液的运动对比度来显示视网膜血管系统。可见光OCT作为一种通过测量视网膜氧输送和代谢率来量化视网膜缺氧的新技术显示出前景。在本文中，我们讨论了这些技术对糖尿病视网膜病变血管病理生理学的最新见解。这些方法的下一个里程碑是大型多中心研究，以就研究糖尿病视网膜病变最可靠和一致的结果参数达成共识。
