Papillon-Smith Jessica, Sobel Mara L, Niles Kirsten M, Solnik M Jonathon, Murji Ally
Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON.
Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON.
J Obstet Gynaecol Can. 2017 Aug;39(8):619-626. doi: 10.1016/j.jogc.2017.01.027. Epub 2017 Jun 7.
To report our experience with the management of Caesarean scar pregnancy (CSP) in the first trimester and to develop a unique treatment algorithm allowing physicians to customize their management based on clinical patient characteristics.
A retrospective review of 12 patients diagnosed with CSP between December 2012 and June 2016 was conducted in a tertiary care hospital in Toronto. All patients were diagnosed with CSP by transvaginal ultrasound using radiologic criteria. Patients were initially treated with an ultrasound-guided embryocidal injection when fetal heart activity was present. Next, patients underwent medical management with systemic multidose methotrexate (MTX) or surgical management using a laparoscopic or transcervical approach depending on CSP characteristics.
The mean age at diagnosis was 35.6 years. The median number of previous CSs was one. The mean serum human chorionic gonadotropin level was 59 938 IU/L. The mean GA at presentation was 8+1 weeks. Two-thirds of patients received medical management with systemic multidose methotrexate. Of these, 50% required additional surgical treatment for the resolution of their CSP. One-third of patients underwent primary surgical treatment, resulting in complete resolution of CSP with no complications. Given the improved outcomes of surgical management in our series, we suggest a treatment algorithm that tailors the surgical approach, either laparoscopic or transcervical, to the characteristics of the CSP.
This constitutes the largest case series of CSP in Canada. Based on our results, CSP can be safely and effectively managed using the suggested surgical algorithm, which accounts for individual patient characteristics.
报告我们在孕早期处理剖宫产瘢痕妊娠(CSP)的经验,并制定一种独特的治疗算法,使医生能够根据患者的临床特征定制治疗方案。
对2012年12月至2016年6月期间在多伦多一家三级护理医院诊断为CSP的12例患者进行回顾性研究。所有患者均通过经阴道超声检查并依据放射学标准诊断为CSP。当存在胎心活动时,患者最初接受超声引导下的胚胎致死注射治疗。接下来,根据CSP的特征,患者接受全身多剂量甲氨蝶呤(MTX)药物治疗或采用腹腔镜或经宫颈入路的手术治疗。
诊断时的平均年龄为35.6岁。既往剖宫产的中位数为1次。血清人绒毛膜促性腺激素的平均水平为59938IU/L。就诊时的平均孕周为8+1周。三分之二的患者接受了全身多剂量甲氨蝶呤的药物治疗。其中,50%的患者需要额外的手术治疗以解决CSP问题。三分之一的患者接受了初次手术治疗,CSP得以完全解决且无并发症。鉴于我们系列研究中手术治疗的效果有所改善,我们建议一种根据CSP特征调整手术入路(腹腔镜或经宫颈)的治疗算法。
这是加拿大最大的CSP病例系列研究。根据我们的结果,使用所建议的考虑个体患者特征的手术算法可以安全有效地处理CSP。