Wang Mingfang, Wang Jinyu, Li Bingcheng, Meng Lingxin, Tian Zhaoxing
Clinical Pharmaceutics Room, Department of Pharmacy, Rizhao Hospital of Traditional Chinese Medicine, Rizhao, Shandong 276800, China.
Department of Oncological, People's Hospital of Rizhao, Rizhao, Shandong 276800, China.
Colloids Surf B Biointerfaces. 2017 Sep 1;157:297-308. doi: 10.1016/j.colsurfb.2017.06.002. Epub 2017 Jun 12.
Co-delivery of chemotherapy drugs and siRNA for cancer therapy has achieved remarkable results according to synergistic/combined antitumor effects, and is recognized as a promising therapeutic modality. However, little attention has been paid to the extremely complex mechanisms of chemotherapy drug-siRNA pairs during co-delivery process. Proper selection of chemotherapy drug-siRNA pairs is beneficial for achieving desirable cancer therapeutic effects. Exploring the inherent principles during chemotherapy drug-siRNA pair selection for co-delivery would greatly enhanced therapeutic efficiency. To achieve ideal results, this article will systematically review current different mechanism-based chemotherapy drug-siRNA pairs for co-delivery in cancer treatment. Large-scale library screening of recent different chemotherapy drug-siRNA pairs for co-delivery would help to establish the chemotherapy drug-siRNA pair selection principle, which could pave the way for co-delivery of chemotherapy drugs and siRNA for cancer treatment in clinic. Following the inherent principle of chemotherapy drug-siRNA pair, more effective co-delivery vectors can be designed in the future.
根据协同/联合抗肿瘤效应，化疗药物和小干扰RNA（siRNA）的共递送在癌症治疗中取得了显著成果，并被认为是一种有前景的治疗方式。然而，在共递送过程中，化疗药物-siRNA对极其复杂的机制却很少受到关注。合理选择化疗药物-siRNA对有利于实现理想的癌症治疗效果。探索化疗药物-siRNA对共递送选择过程中的内在原理将大大提高治疗效率。为了获得理想的结果，本文将系统综述目前用于癌症治疗共递送的基于不同机制的化疗药物-siRNA对。近期对不同化疗药物-siRNA对共递送进行大规模文库筛选将有助于确立化疗药物-siRNA对的选择原则，这可为临床中化疗药物和siRNA共递送用于癌症治疗铺平道路。遵循化疗药物-siRNA对的内在原则，未来可以设计出更有效的共递送载体。
