Kumar Krishan, Rani Varsha, Mishra Mohini, Chawla Ruchi
Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, 221005, U.P., India.
Curr Res Pharmacol Drug Discov. 2022 Apr 28;3:100103. doi: 10.1016/j.crphar.2022.100103. eCollection 2022.
Chemotherapeutics drugs play a pivotal role in the treatment of cancer. However, many issues generate by chemotherapy drugs, including unfavorable harm to healthy cells and multidrug resistance (MDR), persist and have a negative impact on therapeutic outcomes. When compared to monotherapy, combination cancer therapy has many advantages, like improving efficacy through synergistic effects and overcoming drug resistance. Combination treatment may comprise several chemotherapeutics drugs and combinations of chemotherapeutic drugs with some other therapeutic options such as surgery or radiation. Cancer treatment that utilizes co-delivery strategies with siRNA and chemotherapeutic drugs has been shown to have highly effective antitumor effects in the treatment of many cancers. However, the highly complex mechanisms of chemotherapeutic drugs-siRNA pairs during the co-delivery process have received little attention. The ideal combination of chemotherapeutic drugs with siRNA is very crucial for producing the desirable anticancer effects that would greatly enhance therapeutic efficiency. This review puts an emphasis on the logic for choosing suitable chemotherapeutic drug-siRNA combinations, which may open the way for the co-delivery of chemotherapeutic drugs and siRNA for treating cancer in the clinic. This review summarizes recent breakthrough in the area of diverse mechanism-based chemotherapeutic drugs-siRNA combinations in cancer treatment.
化疗药物在癌症治疗中起着关键作用。然而，化疗药物引发的许多问题，包括对健康细胞的不良损害和多药耐药性（MDR），仍然存在并对治疗效果产生负面影响。与单一疗法相比，联合癌症治疗具有许多优势，例如通过协同作用提高疗效和克服耐药性。联合治疗可能包括几种化疗药物以及化疗药物与其他一些治疗选择（如手术或放疗）的组合。利用小干扰RNA（siRNA）和化疗药物的共递送策略进行癌症治疗已被证明在多种癌症的治疗中具有高效的抗肿瘤作用。然而，化疗药物与siRNA在共递送过程中高度复杂的机制却很少受到关注。化疗药物与siRNA的理想组合对于产生理想的抗癌效果至关重要，这将大大提高治疗效率。本综述着重阐述选择合适的化疗药物 - siRNA组合的逻辑，这可能为临床中化疗药物和siRNA的共递送治疗癌症开辟道路。本综述总结了基于不同机制的化疗药物 - siRNA组合在癌症治疗领域的最新突破。
