Lee Yeon Hee, Kim Min-Su, Ahn Seung Il, Park Hye Jin, Shin Kyung Sup, Kim Jung-Yeul
Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Maleunnoon eye clinic, Daejeon, Republic of Korea.
Graefes Arch Clin Exp Ophthalmol. 2017 Sep;255(9):1727-1735. doi: 10.1007/s00417-017-3710-1. Epub 2017 Jun 11.
To analyze the repeatability of thickness measurements of the central macula, ganglion cell-inner plexiform layer (GC-IPL), and retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography (SD-OCT) before and after treatment of macular edema in branch retinal vein occlusion (BRVO).
We analyzed patients with BRVO who visited our retinal clinic. The repeatability of the thickness measurements were compared using the intraclass correlation coefficient (ICC) and coefficient of variation (COV) of affected versus normal fellow eyes.
The average thicknesses of the central macula, RNFL, and GC-IPL were 371.28 μm, 105.60 μm, and 61.88 μm, respectively, in affected eyes with macular edema before treatment, and the ICCs were 0.978, 0.919, and 0.705, respectively. The average thicknesses were 244.98 μm, 96.70 μm, and 82.70 μm, respectively, in affected eyes without macular edema after treatment, and the ICCs were 0.999, 0.975, and 0.928, respectively. After resolution of macular edema, the average thickness of the GC-IPL increased, whereas that of the central macula and RNFL significantly decreased (P < 0.05); all of the ICCs increased compared to pretreatment values. In normal fellow eyes, the average thicknesses were 250.98 μm, 93.50 μm, and 83.84 μm, respectively, and the ICCs were 0.996, 0.995, and 0.994, respectively.
After treatment of macular edema, the repeatability and thickness of the GC-IPL increased, along with reduction in the central macular thickness. This resulted from auto-segmentation errors following macular contour changes and unstable gazes of the patients due to decreased visual acuities in BRVO with macular edema.
分析视网膜分支静脉阻塞（BRVO）黄斑水肿治疗前后，使用光谱域光学相干断层扫描（SD - OCT）测量黄斑中心、神经节细胞 - 内丛状层（GC - IPL）和视网膜神经纤维层（RNFL）厚度的可重复性。
我们分析了前来我们视网膜诊所就诊的BRVO患者。使用组内相关系数（ICC）和患眼与正常对侧眼的变异系数（COV）比较厚度测量的可重复性。
治疗前黄斑水肿患眼中，黄斑中心、RNFL和GC - IPL的平均厚度分别为371.28μm、105.60μm和61.88μm，ICC分别为0.978、0.919和0.705。治疗后无黄斑水肿的患眼中，平均厚度分别为244.98μm、96.70μm和82.70μm，ICC分别为0.999、0.975和0.928。黄斑水肿消退后，GC - IPL的平均厚度增加，而黄斑中心和RNFL的平均厚度显著降低（P < 0.05）；与治疗前相比，所有ICC均增加。在正常对侧眼中，平均厚度分别为250.98μm、93.50μm和83.84μm，ICC分别为0.996、0.995和0.994。
黄斑水肿治疗后，GC - IPL的可重复性和厚度增加，同时黄斑中心厚度降低。这是由于BRVO合并黄斑水肿患者视力下降导致黄斑轮廓改变后的自动分割误差以及患者注视不稳定所致。
