Zaina Fabio, Pesenti Francesca, Persani Luca, Capodaglio Paolo, Negrini Stefano, Polli Nicoletta
ISICO (Italian Scientific Spine Institute), Via Roberto Bellarmino 13/1, 20141, Milan, MI, Italy.
Division of Eating Disorders, IRCCS Istituto Auxologico Italiano, 20149, Milan, MI, Italy.
Eur Spine J. 2018 Feb;27(2):293-297. doi: 10.1007/s00586-017-5181-9. Epub 2017 Jun 10.
A long debate exists about the connection between anorexia nervosa (AN) and scoliosis due to conflicting evidence. No study so far has evaluated the prevalence of scoliosis in patients with AN. The aim of the study is to evaluate the prevalence of idiopathic scoliosis in patients with AN.
Design: cross-sectional study.
convenience sample of all patients matching the inclusion criteria.
female participants coming from an epidemiological screening for scoliosis.
patients had a diagnosis of AN during adolescence according to the DSM-IV-TR criteria. We applied a two-level screening using a Bunnell scoliometer and a radiograph. We calculated the odds ratio compared with participants coming from a school screening.
Seventy-seven females with AN were compared to 816 females screened for scoliosis. The prevalence of scoliosis in the AN group was 16.9% (OR 5.77, 95% CI 3.12-10.67) with respect to the control group. If we consider as positive only those who received a scoliosis diagnosis during adolescence, the OR would be 3.15 (95% CI 1.55-6.42).
This is the first study performed on patients with AN showing a sixfold greater odds of presenting with scoliosis. A cause-effect relationship cannot be determined due to the design.
由于证据相互矛盾，关于神经性厌食症（AN）与脊柱侧弯之间的联系存在长期争论。迄今为止，尚无研究评估AN患者中脊柱侧弯的患病率。本研究的目的是评估AN患者中特发性脊柱侧弯的患病率。
设计：横断面研究。
符合纳入标准的所有患者的便利样本。
来自脊柱侧弯流行病学筛查的女性参与者。
根据DSM-IV-TR标准，患者在青春期被诊断为AN。我们使用邦内尔脊柱侧弯测量仪和X线片进行两级筛查。我们计算了与来自学校筛查的参与者相比的优势比。
将77名患有AN的女性与816名接受脊柱侧弯筛查的女性进行比较。与对照组相比，AN组中脊柱侧弯的患病率为16.9%（优势比5.77，95%置信区间3.12-10.67）。如果仅将那些在青春期被诊断为脊柱侧弯的患者视为阳性，则优势比为3.15（95%置信区间1.55-6.42）。
这是第一项针对AN患者进行的研究，结果显示出现脊柱侧弯的几率高出六倍。由于研究设计，无法确定因果关系。
