近红外发光 Mn 掺杂 NaYF:Yb,Tm/Fe 上转换纳米粒子氧化还原反应体系用于检测 GSH/Cys/AA。
A near-infrared luminescent Mn-doped NaYF:Yb,Tm/Fe upconversion nanoparticles redox reaction system for the detection of GSH/Cys/AA.
机构信息
Anhui Key Laboratory of Chemo-Biosensing, Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China.
Anhui Key Laboratory of Chemo-Biosensing, Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, PR China.
出版信息
Talanta. 2017 Sep 1;172:95-101. doi: 10.1016/j.talanta.2017.05.031. Epub 2017 May 11.
An upconversion luminescence method was developed for the determination of glutathione (GSH), L-cysteine (Cys) or L-ascorbic acid (AA) based on redox reaction. We synthesized poly(acrylic acid) (PAA)-modified Mn-doped NaYF:Yb,Tm upconversion nanoparticles (UCNPs), and the luminescence of these UCNPs was effectively quenched due to their carboxyl groups coordinating with Fe to form a UCNPs/Fe system. GSH, Cys or AA reduced Fe to Fe, which induced the luminescence recovery of the UCNPs. Under the optimized conditions, wide linear concentration ranges from 0.25-300μM for GSH, 0.5-875μM for Cys and 0.5-350μM for AA were found, and the detection limits (3S/K) were 0.2μM, 0.5μM and 0.2μM, respectively. Thus, the UCNPs/Fe system was successfully applied for sensing GSH, Cys or AA.
上转换发光法是基于氧化还原反应，发展用于测定谷胱甘肽（GSH），半胱氨酸（Cys）或抗坏血酸（AA）的方法。我们合成了聚（丙烯酸）（PAA）修饰的Mn 掺杂的 NaYF：Yb，Tm 上转换纳米粒子（UCNPs），由于它们的羧基与 Fe 配位形成 UCNPs/Fe 体系，这些 UCNPs 的发光被有效猝灭。GSH、Cys 或 AA 将 Fe 还原为 Fe，这诱导了 UCNPs 的发光恢复。在优化条件下，对于 GSH 的线性浓度范围为 0.25-300μM，对于 Cys 的线性浓度范围为 0.5-875μM，对于 AA 的线性浓度范围为 0.5-350μM，检出限（3S/K）分别为 0.2μM、0.5μM 和 0.2μM。因此，成功地将 UCNPs/Fe 体系应用于 GSH、Cys 或 AA 的传感。
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