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用于生物系统中小分子和离子检测的功能化上转换纳米颗粒的最新进展

Recent Advances on Functionalized Upconversion Nanoparticles for Detection of Small Molecules and Ions in Biosystems.

作者信息

Gu Bin, Zhang Qichun

机构信息

School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 Singapore.

Division of Chemistry and Biological ChemistrySchool of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link Singapore 637371 Singapore.

出版信息

Adv Sci (Weinh). 2018 Jan 9;5(3):1700609. doi: 10.1002/advs.201700609. eCollection 2018 Mar.

DOI:10.1002/advs.201700609
PMID:29593963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5867034/
Abstract

Significant progress on upconversion-nanoparticle (UCNP)-based probes is witnessed in recent years. Compared with traditional fluorescent probes (e.g., organic dyes, metal complexes, or inorganic quantum dots), UCNPs have many advantages such as non-autofluorescence, high chemical stability, large light-penetration depth, long lifetime, and less damage to samples. This article focuses on recent achievements in the usage of lanthanide-doped UCNPs as efficient probes for biodetection since 2014. The mechanisms of upconversion as well as the luminescence resonance energy transfer process is introduced first, followed by a detailed summary on the recent researches of UCNP-based biodetections including the detection of inorganic ions, gas molecules, reactive oxygen species, and thiols and hydrogen sulfide.

摘要

近年来，基于上转换纳米粒子（UCNP）的探针取得了重大进展。与传统荧光探针（如有机染料、金属配合物或无机量子点）相比，上转换纳米粒子具有许多优点，如无自发荧光、高化学稳定性、大光穿透深度、长寿命以及对样品的损伤较小。本文重点介绍了自2014年以来镧系掺杂上转换纳米粒子作为生物检测高效探针的最新研究成果。首先介绍了上转换机制以及发光共振能量转移过程，随后详细总结了基于上转换纳米粒子的生物检测的最新研究，包括无机离子、气体分子、活性氧以及硫醇和硫化氢的检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0816/5867034/ce5be700e956/ADVS-5-1700609-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0816/5867034/86883ef96994/ADVS-5-1700609-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0816/5867034/bd78a20624f4/ADVS-5-1700609-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0816/5867034/ce5be700e956/ADVS-5-1700609-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0816/5867034/86883ef96994/ADVS-5-1700609-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0816/5867034/0746e280b647/ADVS-5-1700609-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0816/5867034/196e5a2ab09f/ADVS-5-1700609-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0816/5867034/980cf959b106/ADVS-5-1700609-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0816/5867034/927a3fe9c79f/ADVS-5-1700609-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0816/5867034/bd78a20624f4/ADVS-5-1700609-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0816/5867034/ce5be700e956/ADVS-5-1700609-g007.jpg

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