Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid-IdiPaz, CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain.
Department of Medicine, Preventive Medicine and Public Health Area, School of Medicine and Health Sciences, Universidad de Oviedo, Spain.
Clin Nutr. 2018 Aug;37(4):1271-1278. doi: 10.1016/j.clnu.2017.05.016. Epub 2017 May 23.
The effect of vitamin B intake on physical function is not well known.
To examine the prospective association of the intake of vitamins B6, B12 and folate with physical function impairment in older adults.
We performed a prospective cohort study with 1630 participants from the Seniors-ENRICA study, a cohort of community-dwelling adults aged ≥60 years who were free of physical function impairment at baseline. In 2008-2010, nutrient intake was obtained through a validated computer-assisted face-to-face diet history. Study participants were followed-up through 2012 to assess incident impairment in agility and mobility, as well as impairment in overall physical functioning, defined as a decrease in the physical component summary of the 12-Item Short-Form Health Survey.
Over a median follow-up of 3.5 years, we identified 343 individuals with agility limitation, 212 with mobility limitation, and 457 with decreased overall physical functioning. A significant association was observed between intake of vitamin B6 and lower risk of impaired mobility (odds ratio [OR] for highest vs. lowest tertile: 0.66; 95% confidence interval [CI]:0.44-0.99; p-trend = 0.05). The results lost significance when additionally adjusted for vitamin B12 and folate, however the OR did not materially change. A higher consumption of important sources of vitamin B6, such as fish or fruit, was also related to a lower risk of impaired mobility (OR 100-g increase in fish: 0.50; 95% CI: 0.32-0.79; OR 100-g increase in fruit: 0.92; 95% CI: 0.84-1.01). No association was found between vitamin B12 and folate intake and physical function.
A higher intake of vitamin B6 and of several of its main sources, such as fish and fruit, was associated with lower risk of impaired mobility in Spanish older adults.
维生素 B 摄入对身体功能的影响尚不清楚。
研究维生素 B6、B12 和叶酸的摄入与老年人身体功能障碍的前瞻性关联。
我们进行了一项前瞻性队列研究，共有 1630 名来自 Seniors-ENRICA 研究的参与者，这是一个由社区居住的年龄≥60 岁且基线时无身体功能障碍的成年人组成的队列。在 2008-2010 年，通过经过验证的计算机辅助面对面饮食史获得营养素摄入量。研究参与者随访至 2012 年，以评估敏捷性和移动能力的新发障碍，以及整体身体功能的障碍，定义为 12 项简短健康调查的身体成分综合得分下降。
在中位数为 3.5 年的随访期间，我们确定了 343 名行动受限者、212 名行动受限者和 457 名整体身体功能下降者。维生素 B6 摄入与移动能力受损风险降低之间存在显著关联（最高与最低三分位比的比值比[OR]：0.66；95%置信区间[CI]：0.44-0.99；p 趋势=0.05）。然而，当同时调整维生素 B12 和叶酸时，结果失去了意义，但 OR 没有实质性变化。摄入更多重要的维生素 B6 来源，如鱼或水果，也与移动能力受损风险降低相关（每增加 100 克鱼的 OR：0.50；95%CI：0.32-0.79；每增加 100 克水果的 OR：0.92；95%CI：0.84-1.01）。维生素 B12 和叶酸摄入与身体功能之间没有关联。
较高的维生素 B6 摄入以及几种主要来源，如鱼和水果，与西班牙老年人移动能力受损风险降低相关。
