叶酸、维生素 B6 和维生素 B12 状况与代谢综合征发病率的关系。
Folate, Vitamin B6, and Vitamin B12 Status in Association With Metabolic Syndrome Incidence.
机构信息
Nutrition and Foods Program, School of Family and Consumer Sciences, Texas State University, San Marcos.
Department of Obstetrics and Gynecology, Vagelos College of Physician and Surgeons, Columbia University Irving Medical Center, New York, New York.
出版信息
JAMA Netw Open. 2023 Jan 3;6(1):e2250621. doi: 10.1001/jamanetworkopen.2022.50621.
IMPORTANCE
The associations of B vitamin status with metabolic syndrome (MetS) incidence among the US population remain unclear.
OBJECTIVE
To investigate intakes and serum concentrations of folate, vitamin B6, and vitamin B12 in association with MetS risk in a large US cohort.
DESIGN, SETTING, AND PARTICIPANTS: This prospective study included Black and White young adults in the US who were enrolled from 1985 to 1986 and studied until 2015 to 2016. Diet was assessed using a validated diet history at examination years 0, 7, and 20. Serum concentrations of folate, vitamin B6, and vitamin B12 were assayed at examination years 0, 7, and 15 in a subset of 1430 participants. MetS was ascertained by clinic and laboratory measurements and self-reported medication use. Data were analyzed between January and July 2021.
EXPOSURES
Intakes and serum levels of folate, vitamin B6, and vitamin B12.
MAIN OUTCOMES AND MEASURES
Multivariable Cox proportional hazards regression models were used to calculate hazard ratios (HRs) and 95% CIs for the associations of energy-adjusted B vitamin intakes or serum B vitamin levels with incident MetS.
RESULTS
The study included 4414 participants, with 2225 Black individuals (50.4%) and 2331 women (52.8%). The mean (SD) age at baseline was 24.9 (3.6) years. A total of 1240 incident MetS cases occurred during the 30 years (mean [SD], 22.1 [9.5] years) of follow-up. Compared with the lowest quintile of each energy-adjusted B vitamin intake, the HRs for incident MetS in the highest quintile were 0.39 (95% CI, 0.31-0.49) for folate (P for trend < .001), 0.61 (95% CI, 0.46-0.81) for vitamin B6 (P for trend = .002), and 0.74 (95% CI, 0.58-0.95) for vitamin B12 (P for trend = .008) after adjustment for potential confounders. Similarly, significant inverse associations were observed in the subset with serum data on these B vitamins (folate: HR, 0.23; 95% CI, 0.17-0.33; P for trend < .001; vitamin B6: HR, 0.48; 95% CI, 0.34-0.67; P for trend < .001; and vitamin B12: HR, 0.70; 95% CI, 0.51-0.96; P for trend = .01).
CONCLUSIONS AND RELEVANCE
This prospective cohort study found that intakes and serum concentrations of folate, vitamin B6, and vitamin B12 were inversely associated with incident MetS among Black and White young adults in the US.
重要性
美国人群中 B 族维生素状况与代谢综合征（MetS）发病之间的关联仍不清楚。
目的
在一项大型美国队列研究中，调查叶酸、维生素 B6 和维生素 B12 的摄入量和血清浓度与 MetS 风险之间的关系。
设计、地点和参与者：本前瞻性研究纳入了美国的黑人和白人年轻成年人，他们于 1985 年至 1986 年期间入组，并于 2015 年至 2016 年期间进行了研究。通过在检查年份 0、7 和 20 时使用经过验证的饮食史来评估饮食。在 1430 名参与者的亚组中，在检查年份 0、7 和 15 时检测了血清叶酸、维生素 B6 和维生素 B12 的浓度。通过临床和实验室测量以及自我报告的药物使用来确定 MetS。数据于 2021 年 1 月至 7 月进行分析。
暴露
叶酸、维生素 B6 和维生素 B12 的摄入量和血清水平。
主要结果和测量
多变量 Cox 比例风险回归模型用于计算能量调整后的 B 族维生素摄入量或血清 B 族维生素水平与新发 MetS 之间的关联的风险比（HR）和 95%置信区间。
结果
该研究纳入了 4414 名参与者，其中 2225 名黑人（50.4%）和 2331 名女性（52.8%）。基线时的平均（SD）年龄为 24.9（3.6）岁。在 30 年（平均[SD]，22.1[9.5]年）的随访期间共发生 1240 例新发 MetS 病例。与每种能量调整的 B 族维生素摄入量最低五分位数相比，最高五分位数的新发 MetS 的 HR 分别为：叶酸（趋势 P < 0.001）为 0.39（95%CI，0.31-0.49）；维生素 B6（趋势 P = 0.002）为 0.61（95%CI，0.46-0.81）；维生素 B12（趋势 P = 0.008）为 0.74（95%CI，0.58-0.95），在调整了潜在混杂因素后。同样，在具有这些 B 族维生素血清数据的亚组中观察到显著的负相关（叶酸：HR，0.23；95%CI，0.17-0.33；趋势 P < 0.001；维生素 B6：HR，0.48；95%CI，0.34-0.67；趋势 P < 0.001；维生素 B12：HR，0.70；95%CI，0.51-0.96；趋势 P = 0.01）。
结论和相关性
这项前瞻性队列研究发现，在美国的黑人和白人年轻成年人中，叶酸、维生素 B6 和维生素 B12 的摄入量和血清浓度与新发 MetS 呈负相关。
Zotero 插件