Morris Martha Clare, Evans Denis A, Schneider Julie A, Tangney Christine C, Bienias Julia L, Aggarwal Neelum T
Rush Institute for Healthy Aging, Rush University Medical Center, 1645 W. Jackson #675, Chicago, IL 60612, USA.
J Alzheimers Dis. 2006 Aug;9(4):435-43. doi: 10.3233/jad-2006-9410.
It is currently not known whether dietary intakes of folate and vitamins B12 and B6, co-factors in the methylation of homocysteine, protect against Alzheimer's disease.
To examine the association between risk of incident Alzheimer's disease and dietary intakes of folate, vitamin B-12, and vitamin B-6.
Prospective cohort study.
Geographically defined biracial Chicago community.
1,041 residents, aged 65 years and older, initially free of Alzheimer's disease and followed a median 3.9 years for the development of incident disease.
Probable Alzheimer's disease identified through structured clinical neurological evaluation using standardized criteria.
A total of 162 persons developed incident Alzheimer's disease during follow-up. In logistic regression models adjusted for age, sex, race, education, cognitive activities, APOE-epsilon4, and dietary intakes of vitamin E in food and total niacin, there was no association between risk of developing Alzheimer's disease and quintiles of folate intake or of vitamin B-12 intake. The adjusted odds ratio was 1.6 (95% confidence interval: 0.5, 5.2) for persons in the highest quintile of total folate intake (median of 752.7 microg/d) compared with persons in the lowest quintile of intake (median, 202.8 microg/d). Compared with persons in the first quintile of total vitamin B-12 intake (median, 3.1 microg/d) the odds ratio was 0.6 (95% confidence interval: 0.2, 1.6) for persons in the fifth quintile of intake (median, 20.6 microg/d). Intake of vitamin B-6 was not associated with incident Alzheimer's disease after control for dietary intakes of vitamin E and total niacin.
Dietary intakes of folate, vitamin B-12, or vitamin B-6 do not appear to be associated with the development of Alzheimer's disease.
目前尚不清楚同型半胱氨酸甲基化过程中的辅助因子叶酸、维生素B12和维生素B6的膳食摄入量是否能预防阿尔茨海默病。
研究新发阿尔茨海默病风险与叶酸、维生素B12和维生素B6膳食摄入量之间的关联。
前瞻性队列研究。
地理界定的芝加哥混血社区。
1041名65岁及以上居民，最初无阿尔茨海默病，中位随访3.9年以观察新发疾病情况。
通过使用标准化标准的结构化临床神经学评估确定的可能的阿尔茨海默病。
随访期间共有162人发生新发阿尔茨海默病。在对年龄、性别、种族、教育程度、认知活动、APOE-ε4以及食物中维生素E和总烟酸的膳食摄入量进行校正的逻辑回归模型中，发生阿尔茨海默病的风险与叶酸摄入量或维生素B12摄入量的五分位数之间无关联。总叶酸摄入量最高五分位数（中位数为752.7微克/天）的人群与摄入量最低五分位数（中位数为202.8微克/天）的人群相比，校正后的比值比为1.6（95%置信区间：0.5，5.2）。总维生素B12摄入量第五五分位数（中位数为20.6微克/天）的人群与第一五分位数（中位数为3.1微克/天）的人群相比，比值比为0.6（95%置信区间：0.2，1.6）。在控制了维生素E和总烟酸的膳食摄入量后，维生素B6的摄入量与新发阿尔茨海默病无关联。
叶酸、维生素B12或维生素B6的膳食摄入量似乎与阿尔茨海默病的发生无关。
