Wei Ming-Ming, Zhou Guang-Biao
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Genomics Proteomics Bioinformatics. 2016 Oct;14(5):280-288. doi: 10.1016/j.gpb.2016.03.007. Epub 2016 Jul 7.
As a leading cause of cancer deaths worldwide, lung cancer is a collection of diseases with diverse etiologies which can be broadly classified into small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Lung cancer is characterized by genomic and epigenomic alterations; however, mechanisms underlying lung tumorigenesis remain to be elucidated. Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs that consist of ⩾200 nucleotides but possess low or no protein-coding potential. Accumulating evidence indicates that abnormal expression of lncRNAs is associated with tumorigenesis of various cancers, including lung cancer, through multiple biological mechanisms involving epigenetic, transcriptional, and post-transcriptional alterations. In this review, we highlight the expression and roles of lncRNAs in NSCLC and discuss their potential clinical applications as diagnostic or prognostic biomarkers, as well as therapeutic targets.
作为全球癌症死亡的主要原因，肺癌是一组病因多样的疾病，可大致分为小细胞肺癌（SCLC）和非小细胞肺癌（NSCLC）。肺癌的特征是基因组和表观基因组改变；然而，肺肿瘤发生的潜在机制仍有待阐明。长链非编码RNA（lncRNA）是一组非编码RNA，由不少于200个核苷酸组成，但蛋白质编码潜力低或无。越来越多的证据表明，lncRNA的异常表达通过涉及表观遗传、转录和转录后改变的多种生物学机制，与包括肺癌在内的各种癌症的肿瘤发生相关。在本综述中，我们重点介绍lncRNA在NSCLC中的表达和作用，并讨论它们作为诊断或预后生物标志物以及治疗靶点的潜在临床应用。
