Harries M G, Lacey J, Tee R D, Cayley G R, Taylor A J
Lancet. 1985 May 11;1(8437):1063-6. doi: 10.1016/s0140-6736(85)92368-2.
4 patients in whom Didymella exitialis seemed to be an important cause of their asthma were investigated. All 4 patients had immediate skinprick test reactions and specific IgE antibody to D exitialis and Alternaria alternata. Inhalation of a soluble extract of D exitialis provoked immediate asthmatic reactions in these 4, but not in a skin-prick-test-negative volunteer. Radioallergosorbent inhibition studies with D exitialis and A alternata showed self and cross inhibition, which suggested shared antigens. During summer, 1983, 1 of the 4 recorded peak expiratory flow rate (PEFR) twice a day. Spore counts of D exitialis and A alternata were made during this time. Falls in PEFR occurred when D exitialis spore counts increased, usually after a rainfall. Of 34 allergy clinic patients, 6 had skin-prick test reaction to both fungi, but 2 had reactions to A alternata only and 3 to D exitialis only, which suggests the existence of specific antigens. D exitialis seems to be a cause of late summer asthma. Its importance is not known, but allergy to it may contribute to asthma following thunderstorms.
对4例似乎以毁灭茎点霉作为哮喘重要病因的患者进行了调查。所有4例患者对毁灭茎点霉和链格孢均有即刻皮肤点刺试验反应及特异性IgE抗体。吸入毁灭茎点霉的可溶性提取物可使这4例患者引发即刻哮喘反应，但对1名皮肤点刺试验阴性的志愿者则无此反应。用毁灭茎点霉和链格孢进行的放射变应原吸附抑制研究显示了自身抑制和交叉抑制，这提示存在共同抗原。1983年夏季，4例中的1例每天记录2次呼气峰值流速（PEFR）。在此期间对毁灭茎点霉和链格孢的孢子计数。当毁灭茎点霉孢子计数增加时，通常在降雨后，PEFR会下降。在34例变态反应门诊患者中，6例对两种真菌均有皮肤点刺试验反应，但2例仅对链格孢有反应，3例仅对毁灭茎点霉有反应，这提示存在特异性抗原。毁灭茎点霉似乎是夏末哮喘的一个病因。其重要性尚不清楚，但对其过敏可能导致雷雨后哮喘。
