El Amine El Hadj Olfa, Ayadi Malek, Goucha Aida, Ben Hassouna Jameleddine, Rahal Khaled, El May Ahmed, Gamoudi Amor
Tunis Med. 2016 Aug-Sep;94(8-9):525-530.
Mucinous carcinoma is a particular type of breast cancer characterized by the presence of extracellular mucin and is linked with a more favorable prognosis than invasive breast carcinoma of no special type. It accounts for 1 to 7% of all breast cancers. We propose in this work to study at first the clinic-pathological characteristics and the evolution of 48 cases of mucinous carcinomas. Secondly, we propose to identify through a review of recent literature, the therapeutic management of these carcinomas.
This is a retrospective study, conducted in Salah Azaiez carcinological institute, interesting 48 cases of mucinous carcinoma collected over 19 years. Clinical, radiological and pathological information were collected from medical records.
The mean age of our patients was 57 years. The tumor was single in 41 cases and in 7 cases bifocal. Mammographic aspects were favor of malignancy in 33 cases (75%). It was mixed subtype in 14 cases and pure in 34 cases. Lymph node involvement was noted in 14 cases. The number of metastatic lymph nodes ranged from 1 to 11 with an average of 3. Hormone receptors were positive in 35 tumors (73%). The HER2 showed overexpression in 5 cases. Surgery consisted of a radical treatment for thirty-two patients (66%). Overall survival at 5 years was 75.3% and 59.3% at 10 years. Disease-free survival was 74% at 5 years and 58% at 10 years.
Mucinous carcinoma consists of two distinct subtypes: pure and mixed with different prognosis. Larger data samples with longer follow-up are necessary to achieve an improved understanding of this particular tumor.
黏液癌是一种特殊类型的乳腺癌，其特征是存在细胞外黏液，与非特殊类型的浸润性乳腺癌相比，预后更有利。它占所有乳腺癌的1%至7%。我们在这项工作中首先提议研究48例黏液癌的临床病理特征及病情发展。其次，我们提议通过回顾近期文献来确定这些癌症的治疗方法。
这是一项在萨拉赫·阿扎耶兹癌症研究所进行的回顾性研究，纳入了19年间收集的48例黏液癌病例。从病历中收集临床、放射学和病理学信息。
我们患者的平均年龄为57岁。肿瘤单发41例，双发7例。乳腺钼靶检查结果显示33例（75%）有恶性倾向。其中14例为混合亚型，34例为纯型。14例有淋巴结受累。转移淋巴结数量为1至11个，平均3个。35个肿瘤（73%）的激素受体呈阳性。5例HER2呈过表达。32例患者（66%）接受了根治性手术。5年总生存率为75.3%，10年为59.3%。无病生存率5年时为74%，10年时为58%。
黏液癌由两种不同亚型组成：纯型和混合型，预后不同。需要更大的数据样本和更长的随访时间来更好地了解这种特殊肿瘤。
