G基因中存在180个核苷酸重复的新型人偏肺病毒。
Novel human metapneumovirus with a 180-nucleotide duplication in the G gene.
作者信息
Piñana María, Vila Jorgina, Gimferrer Laura, Valls María, Andrés Cristina, Codina María Gema, Ramón Javier, Martín María Carmen, Fuentes Francisco, Saiz Rosario, Alcubilla Pilar, Rodrigo Carlos, Pumarola Tomàs, Antón Andrés
机构信息
Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.
Pediatric Hospitalization Unit, Department of Pediatrics, Hospital Universitari Maternoinfantil Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
出版信息
Future Microbiol. 2017 Jun;12:565-571. doi: 10.2217/fmb-2016-0211. Epub 2017 Jun 12.
AIM
To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016.
MATERIALS & METHODS: Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis.
RESULTS
A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received. The highest circulation was from February to April, with a prevalence of 3%. Different genetic groups within both genotypes were detected at variable levels. A 180-nucleotide duplication was first characterized within the G gene in nine cases, mostly related to lower respiratory-tract infection.
CONCLUSION
This study reported on the circulation of a novel HMPV with a 180-nucleotide duplication in the G gene, but no clinical changes in related cases were observed. Their prevalence increased during the last season suggesting changes in viral features.
目的
描述2014年至2016年在西班牙巴塞罗那比戈大学医院就诊的儿科患者中人类偏肺病毒（HMPV）的流行情况、基因多样性和临床特征。
材料与方法
从实验室确诊的HMPV呼吸道标本中对部分G基因进行测序，用于后续的系统发育分析。
结果
在收到的6658份标本中，共有121份不同样本经实验室确认为HMPV。最高流行期为2月至4月，流行率为3%。在两种基因型中均检测到不同水平的不同基因群。首次在9例病例的G基因中鉴定出180个核苷酸的重复序列，大多与下呼吸道感染有关。
结论
本研究报告了一种在G基因中有180个核苷酸重复序列的新型HMPV的流行情况，但在相关病例中未观察到临床变化。其流行率在上个季节有所上升，提示病毒特征发生了变化。
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