Rossi A, Campo D, Fortuna M C, Garelli V, Pranteda G, De Vita G, Sorriso-Valvo L, Di Nunno D, Carlesimo M
a Department of Internal Medicine and Medical Specialties , "Sapienza", University of Rome , Rome , Italy.
b Istituto Ortodermico Italiano , Rome , Italy.
J Dermatolog Treat. 2018 Mar;29(2):149-151. doi: 10.1080/09546634.2017.1341610. Epub 2017 Jun 29.
Androgenetic alopecia (AGA) is a common form of scalp hair loss that affects up to 50% of males between 18 and 40 years old. Several molecules are commonly used for the treatment of AGA, acting on different steps of its pathogenesis (Minoxidil, Finasteride, Serenoa repens) and show some side effects. In literature, on the basis of hypertrichosis observed in patients treated with analogues of prostaglandin PGF2a, it was supposed that prostaglandins would have an important role in the hair growth: PGE and PGF2a play a positive role, while PGD2 a negative one.
We carried out a pilot study to evaluate the efficacy of topical cetirizine versus placebo in patients with AGA.
A sample of 85 patients was recruited, of which 67 were used to assess the effectiveness of the treatment with topical cetirizine, while 18 were control patients.
We found that the main effect of cetirizine was an increase in total hair density, terminal hair density and diameter variation from T0 to T1, while the vellus hair density shows an evident decrease. The use of a molecule as cetirizine, with no notable side effects, makes possible a good compliance by patients.
Our results have shown that topical cetirizine 1% is responsible for a significant improvement of the initial framework of AGA.
雄激素性脱发（AGA）是一种常见的头皮脱发形式，影响高达50%的18至40岁男性。几种分子常用于治疗AGA，作用于其发病机制的不同步骤（米诺地尔、非那雄胺、锯叶棕），并显示出一些副作用。在文献中，基于用前列腺素PGF2a类似物治疗的患者中观察到的多毛症，推测前列腺素在头发生长中具有重要作用：PGE和PGF2a起积极作用，而PGD2起消极作用。
我们开展了一项初步研究，以评估外用西替利嗪与安慰剂对AGA患者的疗效。
招募了85名患者样本，其中67名用于评估外用西替利嗪治疗的有效性，而18名是对照患者。
我们发现西替利嗪的主要作用是从T0到T1总毛发密度、终毛密度和直径变化增加，而毳毛密度明显降低。使用像西替利嗪这样没有明显副作用的分子，使患者具有良好的依从性成为可能。
我们的结果表明，1%的外用西替利嗪可显著改善AGA的初始状况。
