Pharmaceutical sciences branch, Islamic Azad University, Tehran, Iran.
Center for Research & Training in Skin Diseases & Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
J Pharm Pharm Sci. 2021;24:191-199. doi: 10.18433/jpps31456.
Prostaglandins play a pivotal role in modulating hair growth cycle. Prostaglandin F2α and prostaglandin E have stimulating and prostaglandin D has inhibitory effects on hair follicle. Cetirizine inhibits release of prostaglandin D2 and stimulates the release of prostaglandin E2. In the present study, the efficacy and safety of twice daily application of topical cetirizine 1% versus minoxidil 5% solutions for 16 weeks were compared in male androgenetic alopecia (AGA).
Forty men, aged 18 to 49 years, were randomly divided into two equal groups to apply either cetirizine 1% or minoxidil 5% solutions. The study was divided into two phases, a 16-week treatment phase either with cetirizine or minoxidil (anagen phase), followed by an 8-week drug-free (telogen phase) with a follow-up when patients used placebo. Efficacy outcomes included the change in total hair density, vellus and terminal hair density, hair diameter and the percentage of hair in anagen and telogen phases from baseline in 16 and 24 weeks.
After 16 weeks, we observed a significant increase in total and vellus hair density in both minoxidil and cetirizine groups, but the improvement was much higher in the minoxidil group. The percentage of hair in the anagen phase also increased in both groups after 16 weeks of treatment, but then diminished after 8 weeks of placebo consumption. No significant adverse reactions associated with the administration of cetirizine solution were reported.
Cetirizine 1% solution was effective in hair growth without any complications for treatment of male AGA.
前列腺素在调节毛发生长周期中起关键作用。前列腺素 F2α 和前列腺素 E 对毛囊有刺激作用，而前列腺素 D 则有抑制作用。西替利嗪可抑制前列腺素 D2 的释放，刺激前列腺素 E2 的释放。本研究比较了每日两次应用 1%西替利嗪和 5%米诺地尔溶液治疗男性雄激素性脱发（AGA）的疗效和安全性。
40 名年龄在 18 至 49 岁的男性患者随机分为两组，分别应用 1%西替利嗪或 5%米诺地尔溶液。研究分为两个阶段，16 周的治疗阶段（生长期），分别应用西替利嗪或米诺地尔，随后 8 周停药（休止期），随访时患者使用安慰剂。疗效指标包括总发密度、毳毛和终毛密度、头发直径以及 16 周和 24 周时生长期和休止期的毛发百分比的变化。
16 周后，我们观察到米诺地尔和西替利嗪组的总发密度和毳毛密度均显著增加，但米诺地尔组的改善更为明显。两组患者在治疗 16 周后生长期的毛发百分比也增加，但在 8 周停药后减少。未报告与西替利嗪溶液给药相关的不良反应。
1%西替利嗪溶液对男性 AGA 的治疗有效，无任何并发症。
