免疫治疗佐剂的应用。
Use of adjuvants for immunotherapy.
作者信息
Circelli Luisa, Tornesello Marialina, Buonaguro Franco M, Buonaguro Luigi
机构信息
a Laboratory of Molecular Biology and Viral Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori , "Fondazione Pascale" - IRCCS , Naples , Italy.
出版信息
Hum Vaccin Immunother. 2017 Aug 3;13(8):1774-1777. doi: 10.1080/21645515.2017.1321725. Epub 2017 Jun 12.
Abstract
Cancer vaccines are designed to stimulate the body's immune system to kill tumor cells. To improve their immunogenicity, vaccine antigens must be combined with adjuvants which are able to stimulate the innate immunity and potentiate the adaptive immune response. In the last years a new generation of adjuvants mimicking the natural microbial ligands have been developed. In particular, several TLR ligands have been extensively explored as vaccine adjuvants and many preclinical and clinical studies have been conducted. However, the road to approval of such adjuvants for clinical use is still to go.
摘要
癌症疫苗旨在刺激人体免疫系统杀死肿瘤细胞。为提高其免疫原性，疫苗抗原必须与能够刺激先天免疫并增强适应性免疫反应的佐剂相结合。近年来，已开发出新一代模拟天然微生物配体的佐剂。特别是，几种Toll样受体（TLR）配体已被广泛探索用作疫苗佐剂，并已开展了许多临床前和临床研究。然而，此类佐剂获批用于临床的道路仍任重道远。
相似文献
1
Use of adjuvants for immunotherapy.免疫治疗佐剂的应用。
Hum Vaccin Immunother. 2017 Aug 3;13(8):1774-1777. doi: 10.1080/21645515.2017.1321725. Epub 2017 Jun 12.
2
DNA vaccines to attack cancer: Strategies for improving immunogenicity and efficacy.DNA 疫苗攻击癌症：提高免疫原性和疗效的策略。
Pharmacol Ther. 2016 Sep;165:32-49. doi: 10.1016/j.pharmthera.2016.05.004. Epub 2016 May 24.
3
[Basic background for adjuvant immunotherapy].[辅助免疫治疗的基础背景]
Nihon Rinsho. 2012 Dec;70(12):2059-65.
4
Adjuvants for cancer vaccines.癌症疫苗佐剂。
Semin Immunol. 2010 Jun;22(3):155-61. doi: 10.1016/j.smim.2010.04.007. Epub 2010 May 21.
5
Toll or toll-free adjuvant path toward the optimal vaccine development.通往最佳疫苗开发的Toll或免费佐剂途径。
J Clin Immunol. 2007 Jul;27(4):363-71. doi: 10.1007/s10875-007-9087-x. Epub 2007 Mar 17.
6
Precision nanoscale patterning of TLR ligands for improved cancer immunotherapy.精确纳米级 TLR 配体图案化用于改善癌症免疫疗法。
Cell Rep Methods. 2024 May 20;4(5):100782. doi: 10.1016/j.crmeth.2024.100782.
7
Immune adjuvants in early life: targeting the innate immune system to overcome impaired adaptive response.生命早期的免疫佐剂：靶向固有免疫系统以克服适应性反应受损。
Immunotherapy. 2009 Sep;1(5):883-95. doi: 10.2217/imt.09.38.
8
Toll-like receptor ligands energize peptide vaccines through multiple paths.Toll样受体配体通过多种途径增强肽疫苗的作用。
Cancer Res. 2007 Sep 1;67(17):7945-7. doi: 10.1158/0008-5472.CAN-07-1652.
9
[Development of Nucleic Acid-Based Adjuvant for Cancer Immunotherapy].[基于核酸的癌症免疫治疗佐剂的研发]
Gan To Kagaku Ryoho. 2015 Sep;42(9):1040-5.
10
Cancer vaccine adjuvants--recent clinical progress and future perspectives.癌症疫苗佐剂——近期临床进展与未来展望
Immunopharmacol Immunotoxicol. 2015 Feb;37(1):1-11. doi: 10.3109/08923973.2014.971963. Epub 2014 Oct 16.
引用本文的文献
1
Mesoporous Silica Nanoparticles as an Ideal Platform for Cancer Immunotherapy: Recent Advances and Future Directions.介孔二氧化硅纳米颗粒作为癌症免疫治疗的理想平台：最新进展和未来方向。
Adv Healthc Mater. 2024 Aug;13(20):e2400323. doi: 10.1002/adhm.202400323. Epub 2024 May 3.
2
Immune modulations of the tumor microenvironment in response to phototherapy.光疗对肿瘤微环境的免疫调节作用
J Innov Opt Health Sci. 2023 May;16(3). doi: 10.1142/s1793545823300070. Epub 2023 Apr 27.
3
Data-driven discovery of innate immunomodulators machine learning-guided high throughput screening.基于数据驱动的固有免疫调节剂发现：机器学习引导的高通量筛选
Chem Sci. 2023 Oct 18;14(44):12747-12766. doi: 10.1039/d3sc03613h. eCollection 2023 Nov 15.
4
Enhanced Chemo-Immunotherapy Strategy Utilizing Injectable Thermosensitive Hydrogel for The Treatment of Diffuse Peritoneal Metastasis in Advanced Colorectal Cancer.利用可注射温敏水凝胶的增强化疗免疫治疗策略治疗晚期结直肠癌弥漫性腹膜转移。
Adv Sci (Weinh). 2023 Dec;10(35):e2303819. doi: 10.1002/advs.202303819. Epub 2023 Oct 24.
5
Introduction of an Ultraviolet C-Irradiated 4T1 Murine Breast Cancer Whole-Cell Vaccine Model.一种紫外线C照射的4T1小鼠乳腺癌全细胞疫苗模型的介绍。
Vaccines (Basel). 2023 Jul 18;11(7):1254. doi: 10.3390/vaccines11071254.
6
Photodynamic Therapy-Mediated Immune Responses in Three-Dimensional Tumor Models.三维肿瘤模型中的光动力疗法介导的免疫反应。
Int J Mol Sci. 2021 Nov 23;22(23):12618. doi: 10.3390/ijms222312618.
7
Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy.肿瘤光动力疗法联合免疫疗法的当前策略
Front Oncol. 2021 Nov 17;11:738323. doi: 10.3389/fonc.2021.738323. eCollection 2021.
8
Pancreatic Cancer and Immunotherapy: A Clinical Overview.胰腺癌与免疫疗法：临床概述
Cancers (Basel). 2021 Aug 17;13(16):4138. doi: 10.3390/cancers13164138.
9
Anti-cancer Immunotherapies Targeting Telomerase.靶向端粒酶的抗癌免疫疗法
Cancers (Basel). 2020 Aug 12;12(8):2260. doi: 10.3390/cancers12082260.
10
Engineered Cell-Membrane-Coated Nanoparticles Directly Present Tumor Antigens to Promote Anticancer Immunity.工程化细胞膜包覆纳米颗粒直接呈递肿瘤抗原以促进抗癌免疫。
Adv Mater. 2020 Jul;32(30):e2001808. doi: 10.1002/adma.202001808. Epub 2020 Jun 15.
本文引用的文献
1
Immunological effects of a novel RNA-based adjuvant in liver cancer patients.一种新型RNA佐剂对肝癌患者的免疫作用。
Cancer Immunol Immunother. 2017 Jan;66(1):103-112. doi: 10.1007/s00262-016-1923-5. Epub 2016 Nov 10.
2
Toll-Like Receptors: Ligands, Cell-Based Models, and Readouts for Receptor Action.Toll样受体：受体作用的配体、基于细胞的模型及检测指标
Methods Mol Biol. 2016;1390:3-27. doi: 10.1007/978-1-4939-3335-8_1.
3
TLR-3 stimulation improves anti-tumor immunity elicited by dendritic cell exosome-based vaccines in a murine model of melanoma.在黑色素瘤小鼠模型中，Toll样受体3（TLR-3）刺激可增强基于树突状细胞外泌体的疫苗所引发的抗肿瘤免疫。
Sci Rep. 2015 Dec 3;5:17622. doi: 10.1038/srep17622.
4
Trial Watch: Peptide-based anticancer vaccines.试验观察：基于肽的抗癌疫苗
Oncoimmunology. 2015 Jan 9;4(4):e974411. doi: 10.4161/2162402X.2014.974411. eCollection 2015 Apr.
5
Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo.定义 TLR3 特异性佐剂，可在体内诱导 NK 和 CTL 激活而不产生显著细胞因子。
Nat Commun. 2015 Feb 18;6:6280. doi: 10.1038/ncomms7280.
6
A novel RNA-based adjuvant combines strong immunostimulatory capacities with a favorable safety profile.一种新型基于 RNA 的佐剂兼具强大的免疫刺激性和良好的安全性。
Int J Cancer. 2015 Jul 15;137(2):372-84. doi: 10.1002/ijc.29402. Epub 2015 Jan 8.
7
Going viral with cancer immunotherapy.癌症免疫疗法的爆红。
Nat Rev Cancer. 2014 Aug;14(8):559-67. doi: 10.1038/nrc3770. Epub 2014 Jul 3.
8
Vaccines for the 21st century.21 世纪的疫苗。
EMBO Mol Med. 2014 Jun;6(6):708-20. doi: 10.1002/emmm.201403876. Epub 2014 Apr 6.
9
Synergistic anticancer effects of Pam3CSK4 and Ara-C on B-cell lymphoma cells.Pam3CSK4 和阿糖胞苷对 B 细胞淋巴瘤细胞的协同抗癌作用。
Clin Cancer Res. 2014 Jul 1;20(13):3485-95. doi: 10.1158/1078-0432.CCR-13-2522. Epub 2014 May 5.
10
Breakthrough of the year 2013. Cancer immunotherapy.2013年度重大突破。癌症免疫疗法。
Science. 2013 Dec 20;342(6165):1432-3. doi: 10.1126/science.342.6165.1432.
Zotero 插件