麻疹-腮腺炎-风疹（MMR）疫苗接种在预防目标感染和非目标感染导致的儿科住院方面的有效性：一项回顾性队列研究。
The effectiveness of measles-mumps-rubella (MMR) vaccination in the prevention of pediatric hospitalizations for targeted and untargeted infections: A retrospective cohort study.
作者信息
La Torre Giuseppe, Saulle Rosella, Unim Brigid, Meggiolaro Angela, Barbato Angelo, Mannocci Alice, Spadea Antonietta
机构信息
a Department of Public Health and Infectious Diseases , "Sapienza" University of Rome , Rome , Italy.
b RM/1 Local Health Unit , Rome , Italy.
出版信息
Hum Vaccin Immunother. 2017 Aug 3;13(8):1879-1883. doi: 10.1080/21645515.2017.1330733. Epub 2017 Jun 12.
OBJECTIVES
To evaluate the effectiveness of the measles-mumps-rubella (MMR) vaccine in reducing hospitalizations for infectious disease, targeted and not targeted, as well as from respiratory diseases in children in Rome.
METHODS
The cohort was recomposed through record linkage of 2 archives (vaccination register and hospital discharge records.
RESULTS
The analysis included 11,004 children. 20.9% did not receive the MMR vaccination, 49% and 30.1% received one and 2 doses. There were no hospitalizations for rubella, 2 for mumps, and 12 for measles. The vaccine was highly protective against measles and mumps hospitalizations (HR = 0.10; 95% CI: 0.03.0.34). Regarding all infectious diseases there were 414 hospitalizations, and the vaccine was protective (HR = 0.29; 95% CI: 0.25 to 0.34). Concerning respiratory diseases, there were 809 admissions (7.4%), and the vaccine was highly protective (HR: 0.18; 95% CI: 0.07 to 0.48).
CONCLUSIONS
MMR vaccination is effective for the primary prevention of target and not targeted infectious diseases and may also limit hospitalizations for respiratory diseases.
目的
评估麻疹-腮腺炎-风疹（MMR）疫苗在减少罗马儿童因传染病（无论是否为目标传染病）以及呼吸系统疾病住院方面的有效性。
方法
通过将两个档案（疫苗接种登记册和医院出院记录）进行记录链接来重新组建队列。
结果
分析纳入了11,004名儿童。20.9%未接种MMR疫苗，49%接种了1剂，30.1%接种了2剂。风疹无住院病例，腮腺炎2例，麻疹12例。该疫苗对预防麻疹和腮腺炎住院具有高度保护作用（风险比[HR]=0.10；95%置信区间[CI]：0.03 - 0.34）。关于所有传染病，有414例住院病例，疫苗具有保护作用（HR = 0.29；95% CI：0.25至0.34）。关于呼吸系统疾病，有809例入院病例（7.4%），疫苗具有高度保护作用（HR：0.18；95% CI：0.07至0.48）。
结论
MMR疫苗对目标和非目标传染病的一级预防有效，也可能减少呼吸系统疾病的住院病例。
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