Department of Pediatrics, Boston Children's Hospital, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Curr Opin Immunol. 2022 Oct;78:102234. doi: 10.1016/j.coi.2022.102234. Epub 2022 Aug 13.
Despite the extraordinary speed and success in SARS-Cov-2 vaccine development, the emergence of variants of concern perplexed the vaccine development community. Neutralizing antibodies waned antibodies waned and were evaded by viral variants, despite the preservation of protection against severe disease and death across vaccinated populations. Similar to other vaccine design efforts, the lack of mechanistic correlates of immunity against Coronavirus Disease 2019, raised questions related to the need for vaccine redesign and boosting. Hence, our limited understanding of mechanistic correlates of immunity - across pathogens - remains a major obstacle in vaccine development. The identification and incorporation of mechanistic correlates of immunity are key to the accelerated design of highly impactful globally relevant vaccines. Systems-biology tools can be applied strategically to define a complete understanding of mechanistic correlates of immunity. Embedding immunological dissection and target immune profile identification, beyond canonical antibody binding and neutralization, may accelerate the design and success of durable protective vaccines.
尽管在 SARS-CoV-2 疫苗开发方面取得了非凡的速度和成功，但令人担忧的变异株的出现令疫苗开发界感到困惑。中和抗体减弱，并且被病毒变异体逃避，尽管在接种人群中仍然对严重疾病和死亡提供保护。与其他疫苗设计工作类似，针对 2019 年冠状病毒病的免疫机制相关性缺乏，引发了与疫苗重新设计和加强针接种相关的问题。因此，我们对免疫机制相关性的理解有限——跨越病原体——仍然是疫苗开发的主要障碍。确定和纳入免疫机制相关性是加速设计具有高度影响力的全球相关疫苗的关键。系统生物学工具可以战略性地应用，以全面了解免疫机制相关性。超越经典的抗体结合和中和，嵌入免疫学剖析和目标免疫特征识别，可能会加速耐用保护性疫苗的设计和成功。
