免疫功能障碍在肥胖相关癌症风险、进展和转移中的作用。
The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis.
机构信息
Department of Nutrition Science, College of Health and Human Sciences, Purdue University, West Lafayette, IN, 47906, USA.
出版信息
Cell Mol Life Sci. 2021 Apr;78(7):3423-3442. doi: 10.1007/s00018-020-03752-z. Epub 2021 Jan 19.
Abstract
Obesity has been linked to an increased risk of and a worse prognosis for several types of cancer. A number of interrelated mediators contribute to obesity's pro-tumor effects, including chronic adipose inflammation and other perturbations of immune cell development and function. Here, we review studies examining the impact of obesity-induced immune dysfunction on cancer risk and progression. While the role of adipose tissue inflammation in obesity-associated cancer risk has been well characterized, the effects of obesity on immune cell infiltration and activity within the tumor microenvironment are not well studied. In this review, we aim to highlight the impact of both adipose-mediated inflammatory signaling and intratumoral immunosuppressive signaling in obesity-induced cancer risk, progression, and metastasis.
摘要
肥胖与多种类型癌症的风险增加和预后恶化有关。许多相互关联的介质促成了肥胖的促肿瘤作用，包括慢性脂肪组织炎症和免疫细胞发育和功能的其他改变。在这里，我们回顾了研究肥胖引起的免疫功能障碍对癌症风险和进展影响的研究。虽然脂肪组织炎症在肥胖相关癌症风险中的作用已经得到很好的描述，但肥胖对肿瘤微环境中免疫细胞浸润和活性的影响还没有得到很好的研究。在这篇综述中，我们旨在强调脂肪介导的炎症信号和肿瘤内免疫抑制信号在肥胖诱导的癌症风险、进展和转移中的影响。
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