Commare Bruno, Schmitt Etienne, Aribi Fallia, Panossian Armen, Vors Jean-Pierre, Pazenok Sergiy, Leroux Frédéric R
University of Strasbourg, CNRS, LCM UMR 7509, 67000 Strasbourg, France.
Bayer S.A.S., 14 Impasse Pierre Baizet, BP 99163, 69263 Lyon CEDEX 09, France.
Molecules. 2017 Jun 12;22(6):977. doi: 10.3390/molecules22060977.
Fluorinated heterocycles are important building blocks in pharmaceutical, agrochemical and material sciences. Therefore, organofluorine chemistry has witnessed high interest in the development of efficient methods for the introduction of emergent fluorinated substituents (EFS) onto heterocycles. In this context, fluoroalkyl amino reagents (FARs)-a class of chemicals that was slightly forgotten over the last decades-has emerged again recently and proved to be a powerful tool for the introduction of various fluorinated groups onto (hetero)aromatic derivatives.
氟化杂环是制药、农用化学品和材料科学中的重要结构单元。因此，有机氟化学领域对开发将新型氟化取代基（EFS）引入杂环的有效方法有着浓厚的兴趣。在这种背景下，氟代烷基氨基试剂（FARs）——一类在过去几十年中曾被略微忽视的化学品——最近再次出现，并被证明是一种将各种氟化基团引入（杂）芳族衍生物的强大工具。
