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Reversal of hepatic coma by benzodiazepine antagonist (Ro 15-1788).

出版信息

Lancet. 1985 Jun 8;1(8441):1324-5.

PMID:2860506
Abstract
摘要

相似文献

1
Reversal of hepatic coma by benzodiazepine antagonist (Ro 15-1788).
Lancet. 1985 Jun 8;1(8441):1324-5.
2
The effects of benzodiazepine-receptor antagonists and partial inverse agonists on acute hepatic encephalopathy in the rat.
Gastroenterology. 1991 Sep;101(3):772-81. doi: 10.1016/0016-5085(91)90538-v.
3
[Prolonged coma caused by diazepam sedation in ventilated patients. Diagnostic and therapeutic use of the benzodiazepine antagonist Ro 15-1788].
Dtsch Med Wochenschr. 1984 Mar 2;109(9):340-4. doi: 10.1055/s-2008-1069192.
4
First clinical investigation of the benzodiazepine antagonist Ro 15-1788 in comatose patients.
Eur Neurol. 1983;22(1):7-11. doi: 10.1159/000115529.
5
Benzodiazepine antagonist Ro 15-1788 in self-poisoning. Diagnostic and therapeutic use.
Arch Intern Med. 1985 Apr;145(4):663-4.
6
Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic encephalopathy in the rat: comparison with uremic encephalopathy.GABAA-苯二氮䓬受体的药理学调节对大鼠肝性脑病的有益作用:与尿毒症性脑病的比较。
Hepatology. 1991 Dec;14(6):963-8.
7
Pharmacokinetics of the selective benzodiazepine antagonist Ro 15-1788 in man.选择性苯二氮䓬拮抗剂Ro 15 - 1788在人体中的药代动力学
Eur J Clin Pharmacol. 1984;27(1):115-7.
8
Flumazenil in cirrhotic patients in hepatic coma: a randomized double-blind placebo-controlled crossover trial.氟马西尼用于肝昏迷肝硬化患者:一项随机双盲安慰剂对照交叉试验。
Hepatology. 1994 Jan;19(1):32-7.
9
Benzodiazepine antagonist (RO 15-1788) in ethanol intoxication: a pilot study.苯二氮䓬拮抗剂(RO 15 - 1788)用于乙醇中毒:一项初步研究。
Eur Neurol. 1985;24(5):352-4. doi: 10.1159/000115824.
10
[Benzodiazepine antagonists in the treatment of heptic encephalopathy].[苯二氮䓬拮抗剂在肝性脑病治疗中的应用]
Leber Magen Darm. 1989 Dec;19(6):322-5.

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Aminophylline and Ephedrine, but Not Flumazenil, Inhibit the Activity of the Excitatory Amino Acid Transporter 3 Expressed in Oocytes and Reverse the Increased Activity by Propofol.氨茶碱和麻黄碱,但不是氟马西尼,抑制在卵母细胞中表达的兴奋性氨基酸转运蛋白 3 的活性,并逆转丙泊酚引起的活性增加。
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Endozepine-4 levels are increased in hepatic coma.肝昏迷时内源性苯二氮䓬-4水平升高。
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Natural endogenous ligands for benzodiazepine receptors in hepatic encephalopathy.
肝性脑病中苯二氮䓬受体的天然内源性配体。
Metab Brain Dis. 2009 Mar;24(1):81-93. doi: 10.1007/s11011-008-9111-8. Epub 2008 Dec 11.
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The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy.神经甾体系统:肝性脑病一个新出现的治疗靶点。
Metab Brain Dis. 2007 Dec;22(3-4):291-308. doi: 10.1007/s11011-007-9065-2.
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Effects of L-acetylcarnitine on cirrhotic patients with hepatic coma: randomized double-blind, placebo-controlled trial.L-乙酰肉碱对肝硬化肝昏迷患者的影响:随机双盲、安慰剂对照试验。
Dig Dis Sci. 2006 Dec;51(12):2242-7. doi: 10.1007/s10620-006-9187-0. Epub 2006 Nov 1.
6
Role of endogenous benzodiazepine ligands and their GABA-A--associated receptors in hepatic encephalopathy.内源性苯二氮䓬配体及其GABA-A相关受体在肝性脑病中的作用。
Metab Brain Dis. 2005 Dec;20(4):425-37. doi: 10.1007/s11011-005-7928-y.
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Pathophysiology of hepatic encephalopathy: a new look at GABA from the molecular standpoint.肝性脑病的病理生理学:从分子角度对γ-氨基丁酸的新认识。
Metab Brain Dis. 2004 Dec;19(3-4):331-43. doi: 10.1023/b:mebr.0000043979.58915.41.
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Increased brain concentrations of endogenous (non-benzodiazepine) GABA-A receptor ligands in human hepatic encephalopathy.人类肝性脑病中内源性(非苯二氮䓬类)γ-氨基丁酸A受体配体的脑内浓度增加。
Metab Brain Dis. 2004 Dec;19(3-4):241-51. doi: 10.1023/b:mebr.0000043974.89820.22.
9
Does ammonia contribute to increased GABA-ergic neurotransmission in liver failure?氨是否会导致肝衰竭时γ-氨基丁酸能神经传递增加?
Metab Brain Dis. 1998 Dec;13(4):351-60. doi: 10.1023/a:1020693026810.
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Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.肝硬化合并肝性脑病患者血浆和脑脊液中苯二氮䓬受体配体浓度:与脑病严重程度及苯二氮䓬类药物摄入的关系
Metab Brain Dis. 1998 Sep;13(3):201-10. doi: 10.1023/a:1023271908568.