Scollo-Lavizzari G, Matthis H
Eur Neurol. 1985;24(5):352-4. doi: 10.1159/000115824.
In 1983, we reported on the excellent efficacy of the benzodiazepine antagonist RO 15-1788 in cases of acute intoxication with diazepam in intensive care medicine. Upon observing a positive effect in a patient who had taken alcohol as well as diazepam a study aiming at establishing the beneficial effect of RO 15-1788 in alcoholic intoxication was started. In the meantime, we discovered a significant amelioration of the cerebral disturbance in patients suffering from hepatic coma by the same benzodiazepine antagonist. The preliminary results of a multicenter study reflecting the beneficial effect of RO 15-1788 in cases of alcohol intoxication will be presented.
1983年，我们报道了苯二氮䓬拮抗剂RO 15 - 1788在重症监护医学中治疗地西泮急性中毒病例时具有出色的疗效。在观察到一名同时服用了酒精和地西泮的患者出现了积极效果后，一项旨在确定RO 15 - 1788对酒精中毒有益作用的研究启动了。与此同时，我们发现同一种苯二氮䓬拮抗剂能显著改善肝昏迷患者的脑部紊乱症状。本文将呈现一项多中心研究的初步结果，该结果反映了RO 15 - 1788在酒精中毒病例中的有益作用。
