Esnault Stephane, Kelly Elizabeth A
University of Wisconsin-Madison School of Medicine and Public Health, Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, 600 Highland Avenue, CSC K4/928, Madison, WI 53792-9988.
Crit Rev Immunol. 2016;36(5):429-444. doi: 10.1615/CritRevImmunol.2017020172.
Compelling evidence has demonstrated that the eosinophils bring negative biological outcomes in several diseases, including eosinophilic asthma and hypereosinophilic syndromes. Eosinophils produce and store a broad range of toxic proteins and other mediators that enhance the inflammatory response and lead to tissue damage. For instance, in asthma, a close relationship has been demonstrated between increased lung eosinophilia, asthma exacerbation, and loss of lung function. The use of an anti-IL-5 therapy in severe eosinophilic asthmatic patients is efficient to reduce exacerbations. However, anti-IL-5-treated patients still display a relatively high amount of functional lung tissue eosinophils, indicating that supplemental therapies are required to damper the eosinophil functions. Our recent published works suggest that compared to IL-5, IL-3 can more strongly and differentially affect eosinophil functions. In this review, we summarize our and other investigations that have compared the effects of the three β-chain receptor cytokines (IL-5, GM-CSF and IL-3) on eosinophil biology. We focus on how IL-3 differentially activates eosinophils compared to IL-5 or GM-CSF.
有力的证据表明，嗜酸性粒细胞在包括嗜酸性粒细胞性哮喘和高嗜酸性粒细胞综合征在内的多种疾病中会带来负面的生物学结果。嗜酸性粒细胞产生并储存多种有毒蛋白质和其他介质，这些物质会增强炎症反应并导致组织损伤。例如，在哮喘中，肺部嗜酸性粒细胞增多、哮喘加重和肺功能丧失之间已被证明存在密切关系。在重度嗜酸性粒细胞性哮喘患者中使用抗IL-5疗法可有效减少病情加重。然而，接受抗IL-5治疗的患者肺部组织中仍存在相对大量的功能性嗜酸性粒细胞，这表明需要补充疗法来抑制嗜酸性粒细胞的功能。我们最近发表的研究表明，与IL-5相比，IL-3对嗜酸性粒细胞功能的影响更强且更具差异性。在这篇综述中，我们总结了我们自己以及其他比较三种β链受体细胞因子（IL-5、GM-CSF和IL-3）对嗜酸性粒细胞生物学影响的研究。我们重点关注与IL-5或GM-CSF相比，IL-3如何差异性地激活嗜酸性粒细胞。
