Danielson David T, Aguilera Nadine S, Auerbach Aaron
Department of Pathology, Walter Reed National Military Medical Center, Bethesda, MD, USA.
University of Virginia Health System, Charlottesville, VA, USA.
Head Neck Pathol. 2025 Jan 28;19(1):10. doi: 10.1007/s12105-025-01751-9.
Eosinophilia is a notable feature in various hematological malignancies, including specific types of leukemias and lymphomas that may occur in the head and neck. In hematologic malignancies, eosinophilia can be primary, driven by genetic abnormalities, or secondary, resulting from cytokine and chemokine production by the neoplastic cells or the tumor microenvironment. This review examines the association between eosinophilia and head and neck hematolymphoid malignancies including Classic Hodgkin lymphoma, T-cell lymphoblastic leukemia, mature T and NK-cell lymphomas, and Langerhans cell histiocytosis. It explores the underlying mechanisms of eosinophilia in these malignancies, highlighting the role of chemokines and cytokines such as IL-5, TARC, and eotaxin. Recognition of eosinophilia may aid in the diagnosis of these conditions and understanding the mechanisms of eosinophilia may provide insights into potential prognostic implications and treatment strategies.
嗜酸性粒细胞增多是各种血液系统恶性肿瘤的一个显著特征，包括可能发生在头颈部的特定类型白血病和淋巴瘤。在血液系统恶性肿瘤中，嗜酸性粒细胞增多可以是原发性的，由基因异常驱动，也可以是继发性的，由肿瘤细胞或肿瘤微环境产生的细胞因子和趋化因子所致。本综述探讨了嗜酸性粒细胞增多与头颈部血液淋巴系统恶性肿瘤之间的关联，这些肿瘤包括经典型霍奇金淋巴瘤、T细胞淋巴母细胞白血病、成熟T和NK细胞淋巴瘤以及朗格汉斯细胞组织细胞增多症。它探讨了这些恶性肿瘤中嗜酸性粒细胞增多的潜在机制，强调了趋化因子和细胞因子如白细胞介素-5、胸腺活化调节趋化因子和嗜酸性粒细胞趋化因子的作用。认识到嗜酸性粒细胞增多可能有助于这些疾病的诊断，而了解嗜酸性粒细胞增多的机制可能为潜在的预后意义和治疗策略提供见解。
