Llanos Adana A M, Rabkin Anna, Bandera Elisa V, Zirpoli Gary, Gonzalez Brian D, Xing Cathleen Y, Qin Bo, Lin Yong, Hong Chi-Chen, Demissie Kitaw, Ambrosone Christine B
Department of Epidemiology, Rutgers School of Public Health, Piscataway, NJ 08854, USA.
Cancer Prevention and Control Program, Division of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.
Carcinogenesis. 2017 Sep 1;38(9):883-892. doi: 10.1093/carcin/bgx060.
Exposures to carcinogens in hair products have been explored as breast cancer risk factors, yielding equivocal findings. We examined hair product use (hair dyes, chemical relaxers and cholesterol or placenta-containing conditioners) among African American (AA) and White women, and explored associations with breast cancer. Multivariable-adjusted models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to describe the associations of interest among 2280 cases (1508 AA and 772 White) and 2005 controls (1290 AA and 715 White). Among controls, hair dye use was more common among Whites than AAs (58 versus 30%), while relaxer (88 versus 5%) and deep conditioner use (59 versus 6%) was more common among AAs. Among AAs, use of dark hair dye shades was associated with increased breast cancer risk (OR = 1.51, 95% CI: 1.20-1.90) and use of dark shades (OR = 1.72, 95% CI: 1.30-2.26) and higher frequency of use (OR = 1.36, 95% CI: 1.01-1.84) were associated with ER+ disease. Among Whites, relaxer use (OR = 1.74, 95% CI: 1.11-2.74) and dual use of relaxers and hair dyes (OR = 2.40, 95% CI: 1.35-4.27) was associated with breast cancer; use of dark hair dyes was associated with increased ER+ disease (OR = 1.54, 95% CI: 1.01-2.33), and relaxer use was associated with increased ER- disease (OR = 2.56, 95% CI: 1.06-6.16). These novel findings provide support a relationship between the use of some hair products and breast cancer. Further examinations of hair products as important exposures contributing to breast cancer carcinogenesis are necessary.
头发产品中的致癌物暴露已被作为乳腺癌风险因素进行研究，但结果并不明确。我们调查了非裔美国（AA）女性和白人女性使用头发产品（染发剂、化学直发剂以及含胆固醇或胎盘的护发素）的情况，并探究了其与乳腺癌的关联。使用多变量调整模型来估计优势比（OR）和95%置信区间（CI），以描述2280例病例（1508例AA女性和772例白人女性）和2005名对照（1290例AA女性和715例白人女性）中感兴趣的关联。在对照中，白人使用染发剂的情况比AA女性更常见（58%对30%），而直发剂（88%对5%）和深层护发素的使用（59%对6%）在AA女性中更常见。在AA女性中，使用深色染发剂与乳腺癌风险增加相关（OR = 1.51，95% CI：1.20 - 1.90），使用深色染发剂（OR = 1.72，95% CI：1.30 - 2.26）以及更高的使用频率（OR = 1.36，95% CI：1.01 - 1.84）与雌激素受体阳性（ER+）疾病相关。在白人中，使用直发剂（OR = 1.74，95% CI：1.11 - 2.74）以及直发剂和染发剂的双重使用（OR = 2.40，95% CI：1.35 - 4.27）与乳腺癌相关；使用深色染发剂与ER+疾病增加相关（OR = 1.54，95% CI：1.01 - 2.33），而使用直发剂与ER - 疾病增加相关（OR = 2.56，95% CI：1.06 - 6.16）。这些新发现支持了某些头发产品的使用与乳腺癌之间的关系。有必要进一步研究头发产品作为导致乳腺癌致癌的重要暴露因素。
