Reina-Campos Miguel, Moscat Jorge, Diaz-Meco Maria
Sanford Burnham Prebys Graduate School of Biomedical Sciences, La Jolla, CA 92037, USA.
Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Curr Opin Cell Biol. 2017 Oct;48:47-53. doi: 10.1016/j.ceb.2017.05.006. Epub 2017 Jun 9.
Tumors are strongly influenced by the surrounding normal tissue, which forms a specialized niche termed the tumor microenvironment (TME). The TME is modeled by cancer cells for their own benefit through a complex array of interactions. The identification of new forms of communication within the TME, which are dependent on the tumor's metabolic activity, has expanded our understanding of this heterocellular regulation and has revealed potential therapeutic targets. This review will summarize recent findings on the metabolic regulation of tumor cells by the TME. The concepts to be discussed include the existence of metabolic intratumoral heterogeneity, the contribution of cancer associated fibroblasts (CAFs) to tumor progression, and the regulation of tumor immunology by tumor-secreted metabolites.
肿瘤受到周围正常组织的强烈影响，周围正常组织形成了一个称为肿瘤微环境（TME）的特殊生态位。肿瘤微环境由癌细胞通过一系列复杂的相互作用进行塑造，以满足自身利益。对肿瘤微环境中依赖于肿瘤代谢活动的新通讯形式的识别，扩展了我们对这种异细胞调节的理解，并揭示了潜在的治疗靶点。本综述将总结肿瘤微环境对肿瘤细胞代谢调节的最新研究结果。将讨论的概念包括肿瘤内代谢异质性的存在、癌症相关成纤维细胞（CAF）对肿瘤进展的贡献以及肿瘤分泌代谢物对肿瘤免疫的调节。
