肿瘤微环境中的代谢相互作用。
Metabolic Interactions in the Tumor Microenvironment.
机构信息
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Department of Radiation Oncology, Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY 10016, USA.
出版信息
Trends Cell Biol. 2017 Nov;27(11):863-875. doi: 10.1016/j.tcb.2017.06.003. Epub 2017 Jul 19.
Tumors are dynamic pseudoorgans that contain numerous cell types interacting to create a unique physiology. Within this network, the malignant cells encounter many challenges and rewire their metabolic properties accordingly. Such changes can be experienced and executed autonomously or through interaction with other cells in the tumor. The focus of this review is on the remodeling of the tumor microenvironment that leads to pathophysiologic interactions that are influenced and shaped by metabolism. They include symbiotic nutrient sharing, nutrient competition, and the role of metabolites as signaling molecules. Examples of such processes abound in normal organismal physiology, and such heterocellular metabolic interactions are repurposed to support tumor metabolism and growth. The importance and ubiquity of these processes are just beginning to be realized, and insights into their role in tumor development and progression are being used to design new drug targets and cancer therapies.
肿瘤是包含多种相互作用以产生独特生理学特性的细胞类型的动态拟器官。在这个网络中，恶性细胞会遇到许多挑战，并相应地调整其代谢特性。这些变化可以通过肿瘤内其他细胞的自主或相互作用来感知和执行。本综述的重点是重塑肿瘤微环境，导致生理病理相互作用受到代谢的影响和塑造。它们包括共生营养物质共享、营养物质竞争以及代谢物作为信号分子的作用。在正常的机体生理学中，此类过程比比皆是，并且这种细胞间代谢相互作用被重新用于支持肿瘤代谢和生长。这些过程的重要性和普遍性才刚刚开始被认识到，对其在肿瘤发生和发展中的作用的深入了解正在被用于设计新的药物靶点和癌症治疗方法。
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